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- Schellman_loop abstract "Schellman Loops (also called Schellman motifs or paperclips) are commonly occurring structural features of proteins and polypeptides. Each has six amino acid residues (labelled residues i to i+5) with two specific inter-mainchain hydrogen bonds and a characteristic main chain dihedral angle conformation. The CO group of residue i is hydrogen-bonded to the NH of residue i+5, and the CO group of residue i+1 is hydrogen-bonded to the NH of residue i+4. Residues i+1, i+2, and i+3 have negative φ (phi) angle values and the phi value of residue i+4 is positive. Schellman loops incorporate a threeamino acid residue RL nest (protein structural motif), in which three mainchain NH groups (from Schellman loop residues i+3 to i+5) form a concavity for hydrogen bonding to carbonyl oxygens. About 2.5% of amino acids in proteins belong to Schellman loops.The majority of Schellman loops (82%) occur at the C-terminus of an alpha-helix such that residues i, i+1, i+2 and i+3 are part of the helix. Over a quarter of helices (28%) have a C-terminal Schellman loop.Occasional Schellman loops occur with seven instead of six residues. In these, the CO group of residue i is hydrogen-bonded to the NH of residue i+6, and the CO group of residue i+1 is hydrogen-bonded to the NH of residue i+5. Rare “left-handed” six-residue Schellman loops occur; these have the same hydrogen bonds, but residues i+1, i+2, and i+3 have positive φ values while the φ value of residue i+4 is negative; the nest is of the LR, rather than the RL, kind.Amino acid propensities for the six Schellman-loop residues have been described. Residue i+4 is the one most-highly conserved, with 70% of amino acids being glycine and none proline.The original Schellman criteria result in the inclusion of features not now regarded as Schellman loops. A newer set of criteria is given above.".
- Schellman_loop wikiPageExternalLink pdbemotif.
- Schellman_loop wikiPageID "41978524".
- Schellman_loop wikiPageRevisionID "606215198".
- Schellman_loop subject Category:Organic_chemistry.
- Schellman_loop subject Category:Protein_structural_motifs.
- Schellman_loop comment "Schellman Loops (also called Schellman motifs or paperclips) are commonly occurring structural features of proteins and polypeptides. Each has six amino acid residues (labelled residues i to i+5) with two specific inter-mainchain hydrogen bonds and a characteristic main chain dihedral angle conformation. The CO group of residue i is hydrogen-bonded to the NH of residue i+5, and the CO group of residue i+1 is hydrogen-bonded to the NH of residue i+4.".
- Schellman_loop label "Schellman loop".
- Schellman_loop sameAs m.0_r_ld2.
- Schellman_loop sameAs Q15845157.
- Schellman_loop sameAs Q15845157.
- Schellman_loop wasDerivedFrom Schellman_loop?oldid=606215198.
- Schellman_loop isPrimaryTopicOf Schellman_loop.