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- Sequence_hypothesis abstract "The sequence hypothesis was first formally proposed in the review "On Protein Synthesis" by Francis Crick in 1958. It states that the sequence of bases in the genetic material (DNA or RNA) determines the sequence of amino acids for which that segment of nucleic acid codes, and this amino acid sequence determines the three-dimensional structure into which the protein folds. The three-dimensional structure of a protein is required for a protein to be functional. This hypothesis then lays the essential link between information stored and inherited in nucleic acids to the chemical processes which enable life to exist.Or, as Crick put it in 1958:"In its simplest form it [the Sequence Hypothesis] assumes that the specificity of a piece of nucleic acid is expressed solely by the sequence of its bases, and that this sequence is a (simple) code for the amino acid sequence of a particular protein.This hypothesis appears to be rather widely held. Its virtue is that it unites several remarkable pairs of generalisations: the central biochemical importance of proteins and the dominating role of genes, and in particular of their nucleic acid; the linearity of protein molecules (considered covalently) and the genetic linearity within the functional gene [...]; the simplicity of the composition of protein molecules and the simplicity of the nucleic acids."This description is further amplified in the article and, in discussing how a protein folds up into its three-dimensional structure, Crick suggested that "the folding is simply a function of the order of the amino acids" in the protein.".
- Sequence_hypothesis wikiPageID "13091426".
- Sequence_hypothesis wikiPageRevisionID "596572074".
- Sequence_hypothesis hasPhotoCollection Sequence_hypothesis.
- Sequence_hypothesis subject Category:Biology_theories.
- Sequence_hypothesis subject Category:Nucleic_acids.
- Sequence_hypothesis type Abstraction100002137.
- Sequence_hypothesis type BiologyTheories.
- Sequence_hypothesis type Chemical114806838.
- Sequence_hypothesis type Cognition100023271.
- Sequence_hypothesis type Compound114818238.
- Sequence_hypothesis type Explanation105793000.
- Sequence_hypothesis type HigherCognitiveProcess105770664.
- Sequence_hypothesis type Macromolecule114944888.
- Sequence_hypothesis type Material114580897.
- Sequence_hypothesis type Matter100020827.
- Sequence_hypothesis type Molecule114682133.
- Sequence_hypothesis type NucleicAcid114964129.
- Sequence_hypothesis type NucleicAcids.
- Sequence_hypothesis type OrganicCompound114727670.
- Sequence_hypothesis type Part113809207.
- Sequence_hypothesis type PhysicalEntity100001930.
- Sequence_hypothesis type Process105701363.
- Sequence_hypothesis type PsychologicalFeature100023100.
- Sequence_hypothesis type Relation100031921.
- Sequence_hypothesis type Substance100019613.
- Sequence_hypothesis type Theory105989479.
- Sequence_hypothesis type Thing100002452.
- Sequence_hypothesis type Thinking105770926.
- Sequence_hypothesis type Unit109465459.
- Sequence_hypothesis comment "The sequence hypothesis was first formally proposed in the review "On Protein Synthesis" by Francis Crick in 1958. It states that the sequence of bases in the genetic material (DNA or RNA) determines the sequence of amino acids for which that segment of nucleic acid codes, and this amino acid sequence determines the three-dimensional structure into which the protein folds. The three-dimensional structure of a protein is required for a protein to be functional.".
- Sequence_hypothesis label "Sequence hypothesis".
- Sequence_hypothesis sameAs m.02z643q.
- Sequence_hypothesis sameAs Q7452467.
- Sequence_hypothesis sameAs Q7452467.
- Sequence_hypothesis sameAs Sequence_hypothesis.
- Sequence_hypothesis wasDerivedFrom Sequence_hypothesis?oldid=596572074.
- Sequence_hypothesis isPrimaryTopicOf Sequence_hypothesis.