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- Serotonin-dopamine_reuptake_inhibitor abstract "A serotonin-dopamine reuptake inhibitor (SDRI) is a drug that acts as a reuptake inhibitor for the monoamine neurotransmitters serotonin and dopamine by blocking the actions of the serotonin transporter (SERT) and dopamine transporter (DAT), respectively. This in turn leads to increased extracellular concentrations of serotonin and dopamine and, therefore, an increase in serotonergic and dopaminergic neurotransmission.Unlike the case of other combination monoamine reuptake inhibitors such as serotonin-norepinephrine reuptake inhibitors (SNRIs) and norepinephrine-dopamine reuptake inhibitors (NDRIs), on account of the very similar chemical structures of their substrates, it is extraordinarily difficult to tease apart affinity for the DAT from the norepinephrine transporter (NET) and inhibit the reuptake of dopamine alone. As a result, selective dopamine reuptake inhibitors (DRIs) are rare, and comparably, SDRIs are even more so. In fact, only two SDRIs are well-established in research at present, which are RTI-83 and UWA-101, though other related compounds are known. However, UWA-101 may also possess some activity as a releasing agent, and if so, unlike RTI-83, it would not be an SDRI in the purest sense and would instead be an SDRA or serotonin-dopamine releasing agent (of which it would be the only one known to currently exist). Manning et al. presented two high-affinity MAT-ligands with good binding selectivity for SERT and DAT, namely the 4-indolyl and 1-naphthyl arylalkylamines ent-16b (Ki 0.82, 3.8, 4840 nM for SERT, DAT, NET) and ent-13b respectively.For additional information on SRIs and DRIs, respectively, please refer to these articles:".
- Serotonin-dopamine_reuptake_inhibitor thumbnail Serotonin-2D-skeletal.svg?width=300.
- Serotonin-dopamine_reuptake_inhibitor wikiPageID "35616296".
- Serotonin-dopamine_reuptake_inhibitor wikiPageRevisionID "593030815".
- Serotonin-dopamine_reuptake_inhibitor hasPhotoCollection Serotonin-dopamine_reuptake_inhibitor.
- Serotonin-dopamine_reuptake_inhibitor subject Category:Drugs_acting_on_the_nervous_system.
- Serotonin-dopamine_reuptake_inhibitor subject Category:Monoamine_reuptake_inhibitors.
- Serotonin-dopamine_reuptake_inhibitor subject Category:Serotonin-dopamine_reuptake_inhibitors.
- Serotonin-dopamine_reuptake_inhibitor type Inhibitor114724436.
- Serotonin-dopamine_reuptake_inhibitor type Matter100020827.
- Serotonin-dopamine_reuptake_inhibitor type PhysicalEntity100001930.
- Serotonin-dopamine_reuptake_inhibitor type Serotonin-dopamineReuptakeInhibitors.
- Serotonin-dopamine_reuptake_inhibitor type Substance100020090.
- Serotonin-dopamine_reuptake_inhibitor comment "A serotonin-dopamine reuptake inhibitor (SDRI) is a drug that acts as a reuptake inhibitor for the monoamine neurotransmitters serotonin and dopamine by blocking the actions of the serotonin transporter (SERT) and dopamine transporter (DAT), respectively.".
- Serotonin-dopamine_reuptake_inhibitor label "Serotonin-dopamine reuptake inhibitor".
- Serotonin-dopamine_reuptake_inhibitor sameAs m.0jl120y.
- Serotonin-dopamine_reuptake_inhibitor sameAs Q17144667.
- Serotonin-dopamine_reuptake_inhibitor sameAs Q17144667.
- Serotonin-dopamine_reuptake_inhibitor sameAs Serotonin-dopamine_reuptake_inhibitor.
- Serotonin-dopamine_reuptake_inhibitor wasDerivedFrom Serotonin-dopamine_reuptake_inhibitor?oldid=593030815.
- Serotonin-dopamine_reuptake_inhibitor depiction Serotonin-2D-skeletal.svg.
- Serotonin-dopamine_reuptake_inhibitor isPrimaryTopicOf Serotonin-dopamine_reuptake_inhibitor.
