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- Single_molecule_real_time_sequencing abstract "Single molecule real time sequencing (also known as SMRT) is a parallelized single molecule DNA sequencing by synthesis technology developed by Pacific Biosciences. Single molecule real time sequencing utilizes the zero-mode waveguide (ZMW), developed in the laboratories of Harold G. Craighead and Watt W. Webb at Cornell University. A single DNA polymerase enzyme is affixed at the bottom of a ZMW with a single molecule of DNA as a template. The ZMW is a structure that creates an illuminated observation volume that is small enough to observe only a single nucleotide of DNA (also known as a base) being incorporated by DNA polymerase. Each of the four DNA bases is attached to one of four different fluorescent dyes. When a nucleotide is incorporated by the DNA polymerase, the fluorescent tag is cleaved off and diffuses out of the observation area of the ZMW where its fluorescence is no longer observable. A detector detects the fluorescent signal of the nucleotide incorporation, and the base call is made according to the corresponding fluorescence of the dye. Sequence data generated from single molecule real time sequencing was first published in January 2009 in the journal Science.".
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- Single_molecule_real_time_sequencing wikiPageID "16020703".
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- Single_molecule_real_time_sequencing hasPhotoCollection Single_molecule_real_time_sequencing.
- Single_molecule_real_time_sequencing subject Category:Bioinformatics.
- Single_molecule_real_time_sequencing subject Category:DNA_sequencing.
- Single_molecule_real_time_sequencing subject Category:Genomics.
- Single_molecule_real_time_sequencing comment "Single molecule real time sequencing (also known as SMRT) is a parallelized single molecule DNA sequencing by synthesis technology developed by Pacific Biosciences. Single molecule real time sequencing utilizes the zero-mode waveguide (ZMW), developed in the laboratories of Harold G. Craighead and Watt W. Webb at Cornell University. A single DNA polymerase enzyme is affixed at the bottom of a ZMW with a single molecule of DNA as a template.".
- Single_molecule_real_time_sequencing label "Single molecule real time sequencing".
- Single_molecule_real_time_sequencing label "Одномолекулярное секвенирование в реальном времени".
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- Single_molecule_real_time_sequencing sameAs Q13080815.
- Single_molecule_real_time_sequencing sameAs Q13080815.
- Single_molecule_real_time_sequencing wasDerivedFrom Single_molecule_real_time_sequencing?oldid=601347592.
- Single_molecule_real_time_sequencing isPrimaryTopicOf Single_molecule_real_time_sequencing.