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DBpedia 2014

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Sirolimus abstract "Sirolimus (INN/USAN), also known as rapamycin, is a macrolide produced by the bacteria Streptomyces hygroscopicus. It has immunosuppressant functions in humans and is used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B cells by inhibiting their response to interleukin-2 (IL-2). Sirolimus is also used as a coronary stent coating. Sirolimus works, in part, by eliminating old and abnormal white blood cells.[citation needed] Sirolimus is effective in mice with autoimmunity and in children with a rare condition called autoimmune lymphoproliferative syndrome (ALPS).Sirolimus was discovered by Brazilian researchers in a soil sample from Easter Island, also known as Rapa Nui. It was approved by the US Food and Drug Administration in September 1999 and is marketed under the trade name Rapamune by Pfizer (formerly by Wyeth).Sirolimus was originally developed as an antifungal agent. However, this use was abandoned when it was discovered to have potent immunosuppressive and antiproliferative properties. It has since been shown to prolong the life of mice and might also be useful in the treatment of certain cancers.".
Sirolimus atcPrefix "L04".
Sirolimus atcSuffix "AA10".
Sirolimus bioavailability "20.0".
Sirolimus casNumber "53123-88-9".
Sirolimus chEBI "9168".
Sirolimus drugbank "DB00877".
Sirolimus fdaUniiCode "W36ZG6FT64".
Sirolimus iupacName "(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,".
Sirolimus iupacName "(4H,6H,31H)-pentone".
Sirolimus iupacName "1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-".
Sirolimus iupacName "26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,".
Sirolimus iupacName "27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-".
Sirolimus iupacName "[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-".
Sirolimus iupacName "hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]-".
Sirolimus iupacName "oxaazacyclohentriacontine-1,5,11,28,29".
Sirolimus pubchem "5284616".
Sirolimus thumbnail Sirolimus.svg?width=300.
Sirolimus wikiPageExternalLink www.rapamune.com.
Sirolimus wikiPageID "529476".
Sirolimus wikiPageRevisionID "606597073".
Sirolimus atcPrefix "L04".
Sirolimus atcSuffix "AA10".
Sirolimus bioavailability "20".
Sirolimus c "51".
Sirolimus casNumber "53123".
Sirolimus chebi "9168".
Sirolimus chembl "413".
Sirolimus chemspiderid "10482078".
Sirolimus drugbank "DB00877".
Sirolimus eliminationHalfLife "226800.0".
Sirolimus excretion "Mostly faecal".
Sirolimus h "79".
Sirolimus hasPhotoCollection Sirolimus.
Sirolimus image "Sirolimus-from-1C9H-3D-sticks.png".
Sirolimus inchi "1".
Sirolimus inchikey "QFJCIRLUMZQUOT-HPLJOQBZBU".
Sirolimus iupacName "-9223372036854775808".
Sirolimus iupacName "-pentone".
Sirolimus iupacName "1".
Sirolimus iupacName "2732333434".
Sirolimus iupacName "[-2-[-4-hydroxy-3-methoxycyclohexyl]-".
Sirolimus iupacName "hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]-".
Sirolimus iupacName "oxaazacyclohentriacontine-1,5,11,28,29".
Sirolimus kegg "D00753".
Sirolimus legalUs "Rx-only".
Sirolimus licenceEu "Rapamune".
Sirolimus licenceUs "Sirolimus".
Sirolimus metabolism "Hepatic".
Sirolimus molecularWeight "914.172".
Sirolimus n "1".
Sirolimus o "13".
Sirolimus pdbLigand "RAP".
Sirolimus pregnancyAu "C".
Sirolimus pregnancyUs "C".
Sirolimus proteinBound "92.0".
Sirolimus pubchem "5284616".
Sirolimus routesOfAdministration "Oral".
Sirolimus smiles "O[C@@H]1CC[C@H]C[C@@H][C@@H]4CC[C@H]/C=C[C@@H][C@@H]C[C@H]C[C@H]\C=C\C=C\C=C[C@@H]C[C@@H]2CC[C@@H][C@@]CCN3CCCC[C@H]3CO4".
Sirolimus stdinchi "1".
Sirolimus stdinchikey "QFJCIRLUMZQUOT-HPLJOQBZSA-N".
Sirolimus unii "W36ZG6FT64".
Sirolimus verifiedfields "changed".
Sirolimus verifiedrevid "464392064".
Sirolimus width "250".
Sirolimus subject Category:Anti-aging_substances.
Sirolimus subject Category:Immunosuppressants.
Sirolimus subject Category:Lactams.
Sirolimus subject Category:Macrolides.
Sirolimus subject Category:Requests_for_audio_pronunciation_(English).
Sirolimus type Artifact100021939.
Sirolimus type Commodity103076708.
Sirolimus type Merchandise103748886.
Sirolimus type NaturalProducts.
Sirolimus type Object100002684.
Sirolimus type PhysicalEntity100001930.
Sirolimus type Whole100003553.
Sirolimus type Drug.
Sirolimus type DrugProduct.
Sirolimus type FunctionalSubstance.
Sirolimus comment "Sirolimus (INN/USAN), also known as rapamycin, is a macrolide produced by the bacteria Streptomyces hygroscopicus. It has immunosuppressant functions in humans and is used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B cells by inhibiting their response to interleukin-2 (IL-2). Sirolimus is also used as a coronary stent coating.".
Sirolimus label "Sirolimus".
Sirolimus label "Sirolimus".
Sirolimus label "Sirolimus".
Sirolimus label "Sirolimus".
Sirolimus label "Sirolimus".
Sirolimus label "Sirolimus".
Sirolimus label "Sirolimus".
Sirolimus label "Sirolimus".
Sirolimus label "Сиролимус".
Sirolimus label "سيروليمس".
Sirolimus label "ラパマイシン".
Sirolimus label "雷帕霉素".
Sirolimus sameAs Sirolimus.
Sirolimus sameAs Sirolimus.
Sirolimus sameAs Sirolimus.
Sirolimus sameAs Sirolimus.
Sirolimus sameAs ラパマイシン.
Sirolimus sameAs 시롤리무스.
Sirolimus sameAs Sirolimus.