Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Smoothened> ?p ?o. }
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- Smoothened abstract "Smoothened is a G protein-coupled receptor protein encoded by the SMO gene of the hedgehog signaling pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine.Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium. Furthermore, SMO that is mutated in the domain required for ciliary localisation cannot contribute to pathway activation. SMO has also been shown to bind the kinesin motor protein Costal-2 and play a role in the localization of the Ci (Cubitus interruptus transcription factor) complex.SMO can function as an oncogene. Activating SMO mutations can lead to unregulated activation of the hedgehog pathway and cancer.".
- Smoothened entrezgene "6608".
- Smoothened thumbnail Signal_transduction_pathways.svg?width=300.
- Smoothened wikiPageExternalLink ReceptorDisplayForward?receptorID=3069.
- Smoothened wikiPageID "5230538".
- Smoothened wikiPageRevisionID "593064730".
- Smoothened hasPhotoCollection Smoothened.
- Smoothened requireManualInspection "no".
- Smoothened updateCitations "yes".
- Smoothened updatePage "yes".
- Smoothened updateProteinBox "yes".
- Smoothened updateSummary "no".
- Smoothened subject Category:7TM_receptors.
- Smoothened subject Category:G_protein_coupled_receptors.
- Smoothened type 7TMReceptors.
- Smoothened type BodyPart105220461.
- Smoothened type GProteinCoupledReceptors.
- Smoothened type Part109385911.
- Smoothened type PhysicalEntity100001930.
- Smoothened type Receptor105608868.
- Smoothened type Structure105225602.
- Smoothened type Thing100002452.
- Smoothened type Biomolecule.
- Smoothened type Protein.
- Smoothened type BiologicalObject.
- Smoothened comment "Smoothened is a G protein-coupled receptor protein encoded by the SMO gene of the hedgehog signaling pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine.Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium.".
- Smoothened label "Smoothened".
- Smoothened label "Smoothened".
- Smoothened label "Smoothened".
- Smoothened label "Smoothened".
- Smoothened sameAs Smoothened.
- Smoothened sameAs Smoothened.
- Smoothened sameAs Smoothened.
- Smoothened sameAs m.0d90jz.
- Smoothened sameAs Q3271551.
- Smoothened sameAs Q3271551.
- Smoothened sameAs Smoothened.
- Smoothened wasDerivedFrom Smoothened?oldid=593064730.
- Smoothened depiction Signal_transduction_pathways.svg.
- Smoothened isPrimaryTopicOf Smoothened.
