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- Smoothened_agonist abstract "Smoothened agonist (SAG) was one of the first small-molecule agonists developed for the protein Smoothened, a key part of the hedgehog signaling pathway, which is involved in brain development as well as having a number of other functions in the body. Smoothened agonist has been shown to aid proliferation and survival of developing neurons, and prevent drug induced brain injury. When injected into the cerebellum of newborn mice with an induced Down's syndrome like condition, Smoothened agonist was able to stimulate normal cerebellum development resulting in significant behavioural improvement once the mice had grown to adulthood.".
- Smoothened_agonist casNumber "912545-86-9".
- Smoothened_agonist casSupplemental "364590-63-6 (hydrochloride)".
- Smoothened_agonist iupacName "3-chloro-N-[(1r,4r)-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]benzo[b]thiophene-2-carboxamide".
- Smoothened_agonist pubchem "5284330".
- Smoothened_agonist thumbnail Smoothened2DACS.svg?width=300.
- Smoothened_agonist wikiPageID "40456795".
- Smoothened_agonist wikiPageRevisionID "602276701".
- Smoothened_agonist c "28".
- Smoothened_agonist casNumber "912545".
- Smoothened_agonist casSupplemental "364590".
- Smoothened_agonist cl "1".
- Smoothened_agonist h "28".
- Smoothened_agonist iupacName "3".
- Smoothened_agonist molecularWeight "490.06".
- Smoothened_agonist n "3".
- Smoothened_agonist o "1".
- Smoothened_agonist pubchem "5284330".
- Smoothened_agonist s "1".
- Smoothened_agonist smiles "ClC1=CSC5=CC=CC=C51".
- Smoothened_agonist width "260".
- Smoothened_agonist subject Category:Down_syndrome.
- Smoothened_agonist subject Category:Receptor_agonists.
- Smoothened_agonist type Drug.
- Smoothened_agonist type FunctionalSubstance.
- Smoothened_agonist comment "Smoothened agonist (SAG) was one of the first small-molecule agonists developed for the protein Smoothened, a key part of the hedgehog signaling pathway, which is involved in brain development as well as having a number of other functions in the body. Smoothened agonist has been shown to aid proliferation and survival of developing neurons, and prevent drug induced brain injury.".
- Smoothened_agonist label "Smoothened agonist".
- Smoothened_agonist sameAs m.0wzt69p.
- Smoothened_agonist sameAs Q15410188.
- Smoothened_agonist sameAs Q15410188.
- Smoothened_agonist wasDerivedFrom Smoothened_agonist?oldid=602276701.
- Smoothened_agonist depiction Smoothened2DACS.svg.
- Smoothened_agonist isPrimaryTopicOf Smoothened_agonist.