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- Solabegron abstract "Solabegron (GW-427,353) is a drug which acts as a selective agonist for the β3 adrenergic receptor. It is being developed for the treatment of overactive bladder and irritable bowel syndrome. It has been shown to produce visceral analgesia by releasing somatostatin from adipocytes.,Solabegron was discovered by GlaxoSmithKline and acquired by AltheRx in March 2011. Solabegron relaxes the bladder smooth muscle by stimulating beta-3 adrenoceptors, a novel mechanism compared to older established drug treatments for overactive bladder syndrome such as the anticholinergic agents. Astellas Pharma have developed the first commercially available β3 adrenergic receptor, mirabegron, which is now licensed in Japan and the US for overactive bladder. Mirabegron is not licensed for irritable bowel syndrome.A Phase II study of Solabegron for overactive bladder (OAB) looked at 258 patients with moderate to severe incontinence experiencing an average of 4.5 wet episodes per day. Results demonstrated a statistically significant improvement with Solabegron as compared to placebo, as measured by the percent reduction of the number of wet episodes and the absolute number of daily voids.A Phase II study for irritable bowel syndrome (IBS) evaluated 102 patients with IBS. Solabegron demonstrated significant reduction in pain associated with the disorder and a trend for greater improvement in the quality of life, compared to placebo.Both Phase II studies indicated a tolerability profile for Solabegron that was similar to placebo. The OAB patients did not suffer from dry mouth, constipation, increase in heart rate or cognitive issues.AltheRx is currently preparing to advance Solabegron into a large clinical study in OAB.".
- Solabegron atcPrefix "none".
- Solabegron casNumber "451470-34-1".
- Solabegron fdaUniiCode "55P6YH9O6N".
- Solabegron iupacName "3'-[(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)amino]biphenyl-3-carboxylic acid".
- Solabegron pubchem "6433123".
- Solabegron thumbnail Solabegron-2d-skeletal.png?width=300.
- Solabegron wikiPageID "17846970".
- Solabegron wikiPageRevisionID "545345631".
- Solabegron atcPrefix "none".
- Solabegron c "23".
- Solabegron casNumber "451470".
- Solabegron cl "1".
- Solabegron h "23".
- Solabegron hasPhotoCollection Solabegron.
- Solabegron iupacName "3".
- Solabegron kegg "D05879".
- Solabegron molecularWeight "410.892".
- Solabegron n "2".
- Solabegron o "3".
- Solabegron pubchem "6433123".
- Solabegron smiles "OCccccc2-c1ccNCCNCCc3ccccc3".
- Solabegron synonyms "(3-benzoic acid)".
- Solabegron unii "55".
- Solabegron verifiedrevid "443452701".
- Solabegron watchedfields "changed".
- Solabegron subject Category:Alcohols.
- Solabegron subject Category:Anilines.
- Solabegron subject Category:Benzoic_acids.
- Solabegron subject Category:Beta-adrenergic_agonists.
- Solabegron subject Category:Biphenyls.
- Solabegron subject Category:Organochlorides.
- Solabegron type Abstraction100002137.
- Solabegron type Acid114607521.
- Solabegron type Agent114778436.
- Solabegron type Alcohol107884567.
- Solabegron type Alcohols.
- Solabegron type AliphaticCompound114601294.
- Solabegron type Amine114739004.
- Solabegron type Aniline114754505.
- Solabegron type Anilines.
- Solabegron type BenzoicAcid114775321.
- Solabegron type BenzoicAcids.
- Solabegron type Beverage107881800.
- Solabegron type CarboxylicAcid114739360.
- Solabegron type CausalAgent100007347.
- Solabegron type Chemical114806838.
- Solabegron type Compound114818238.
- Solabegron type Drug103247620.
- Solabegron type DrugOfAbuse103248958.
- Solabegron type Fluid114939900.
- Solabegron type Food100021265.
- Solabegron type Liquid114940386.
- Solabegron type Material114580897.
- Solabegron type Matter100020827.
- Solabegron type MethaneSeries114951377.
- Solabegron type OrganicCompound114727670.
- Solabegron type Part113809207.
- Solabegron type PhysicalEntity100001930.
- Solabegron type Relation100031921.
- Solabegron type Substance100019613.
- Solabegron type Substance100020090.
- Solabegron type Drug.
- Solabegron type DrugProduct.
- Solabegron type FunctionalSubstance.
- Solabegron comment "Solabegron (GW-427,353) is a drug which acts as a selective agonist for the β3 adrenergic receptor. It is being developed for the treatment of overactive bladder and irritable bowel syndrome. It has been shown to produce visceral analgesia by releasing somatostatin from adipocytes.,Solabegron was discovered by GlaxoSmithKline and acquired by AltheRx in March 2011.".
- Solabegron label "Solabegron".
- Solabegron sameAs m.047g6cl.
- Solabegron sameAs Q7555630.
- Solabegron sameAs Q7555630.
- Solabegron sameAs Solabegron.
- Solabegron wasDerivedFrom Solabegron?oldid=545345631.
- Solabegron depiction Solabegron-2d-skeletal.png.
- Solabegron isPrimaryTopicOf Solabegron.
