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- Sterol_regulatory_element-binding_protein abstract "Sterol Regulatory Element-Binding Proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. Mammalian SREBPs are encoded by the genes SREBF1 and SREBF2. SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to the nuclear envelope and endoplasmic reticulum membranes. In cells with low levels of sterols, SREBPs are cleaved to a water soluble N-terminal domain that is translocated to the nucleus. These activated SREBPs then bind to specific sterol regulatory element DNA sequences, thus upregulating the synthesis of enzymes involved in sterol biosynthesis. Sterols in turn inhibit the cleavage of SREBPs and therefore synthesis of additional sterols is reduced through a negative feed back loop.".
- Sterol_regulatory_element-binding_protein arm "p".
- Sterol_regulatory_element-binding_protein arm "q".
- Sterol_regulatory_element-binding_protein band "11.2".
- Sterol_regulatory_element-binding_protein band "13".
- Sterol_regulatory_element-binding_protein chromosome "17".
- Sterol_regulatory_element-binding_protein chromosome "22".
- Sterol_regulatory_element-binding_protein entrezgene "6720".
- Sterol_regulatory_element-binding_protein entrezgene "6721".
- Sterol_regulatory_element-binding_protein hgncid "11289".
- Sterol_regulatory_element-binding_protein hgncid "11290".
- Sterol_regulatory_element-binding_protein omim "184756".
- Sterol_regulatory_element-binding_protein omim "600481".
- Sterol_regulatory_element-binding_protein pdb "1am9".
- Sterol_regulatory_element-binding_protein refseq "NM_004176".
- Sterol_regulatory_element-binding_protein refseq "NM_004599".
- Sterol_regulatory_element-binding_protein symbol "SREBF1".
- Sterol_regulatory_element-binding_protein symbol "SREBF2".
- Sterol_regulatory_element-binding_protein thumbnail Sterol_Regulatory_Element_Binding_Protein_1A.png?width=300.
- Sterol_regulatory_element-binding_protein uniprot "P36956".
- Sterol_regulatory_element-binding_protein uniprot "Q12772".
- Sterol_regulatory_element-binding_protein wikiPageExternalLink explore.do?structureId=1AM9.
- Sterol_regulatory_element-binding_protein wikiPageExternalLink cholesterol.htm.
- Sterol_regulatory_element-binding_protein wikiPageExternalLink lab.html.
- Sterol_regulatory_element-binding_protein wikiPageID "4917048".
- Sterol_regulatory_element-binding_protein wikiPageRevisionID "593096272".
- Sterol_regulatory_element-binding_protein arm "p".
- Sterol_regulatory_element-binding_protein arm "q".
- Sterol_regulatory_element-binding_protein band "11.2".
- Sterol_regulatory_element-binding_protein band "13".
- Sterol_regulatory_element-binding_protein caption "X-ray crystallography of Sterol Regulatory Element Binding Protein 1A with polydeoxyribonucleotide.".
- Sterol_regulatory_element-binding_protein chromosome "17".
- Sterol_regulatory_element-binding_protein chromosome "22".
- Sterol_regulatory_element-binding_protein entrezgene "6720".
- Sterol_regulatory_element-binding_protein entrezgene "6721".
- Sterol_regulatory_element-binding_protein hasPhotoCollection Sterol_regulatory_element-binding_protein.
- Sterol_regulatory_element-binding_protein hgncid "11289".
- Sterol_regulatory_element-binding_protein hgncid "11290".
- Sterol_regulatory_element-binding_protein name "sterol regulatory element-binding transcription factor 1".
- Sterol_regulatory_element-binding_protein name "sterol regulatory element-binding transcription factor 2".
- Sterol_regulatory_element-binding_protein omim "184756".
- Sterol_regulatory_element-binding_protein omim "600481".
- Sterol_regulatory_element-binding_protein pdb "1".
- Sterol_regulatory_element-binding_protein refseq "NM_004176".
- Sterol_regulatory_element-binding_protein refseq "NM_004599".
- Sterol_regulatory_element-binding_protein symbol "SREBF1".
- Sterol_regulatory_element-binding_protein symbol "SREBF2".
- Sterol_regulatory_element-binding_protein uniprot "P36956".
- Sterol_regulatory_element-binding_protein uniprot "Q12772".
- Sterol_regulatory_element-binding_protein subject Category:Transcription_factors.
- Sterol_regulatory_element-binding_protein type Abstraction100002137.
- Sterol_regulatory_element-binding_protein type Beginning107290905.
- Sterol_regulatory_element-binding_protein type Cause107326557.
- Sterol_regulatory_element-binding_protein type Event100029378.
- Sterol_regulatory_element-binding_protein type Factor107327805.
- Sterol_regulatory_element-binding_protein type Happening107283608.
- Sterol_regulatory_element-binding_protein type Origin107323922.
- Sterol_regulatory_element-binding_protein type PsychologicalFeature100023100.
- Sterol_regulatory_element-binding_protein type TranscriptionFactors.
- Sterol_regulatory_element-binding_protein type YagoPermanentlyLocatedEntity.
- Sterol_regulatory_element-binding_protein type Biomolecule.
- Sterol_regulatory_element-binding_protein type Protein.
- Sterol_regulatory_element-binding_protein type BiologicalObject.
- Sterol_regulatory_element-binding_protein comment "Sterol Regulatory Element-Binding Proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. Mammalian SREBPs are encoded by the genes SREBF1 and SREBF2. SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to the nuclear envelope and endoplasmic reticulum membranes.".
- Sterol_regulatory_element-binding_protein label "SREBP".
- Sterol_regulatory_element-binding_protein label "Sterol regulatory element-binding protein".
- Sterol_regulatory_element-binding_protein sameAs SREBP.
- Sterol_regulatory_element-binding_protein sameAs Protein_SREB.
- Sterol_regulatory_element-binding_protein sameAs m.0cv24c.
- Sterol_regulatory_element-binding_protein sameAs Q416064.
- Sterol_regulatory_element-binding_protein sameAs Q416064.
- Sterol_regulatory_element-binding_protein sameAs Sterol_regulatory_element-binding_protein.
- Sterol_regulatory_element-binding_protein wasDerivedFrom Sterol_regulatory_element-binding_protein?oldid=593096272.
- Sterol_regulatory_element-binding_protein depiction Sterol_Regulatory_Element_Binding_Protein_1A.png.
- Sterol_regulatory_element-binding_protein isPrimaryTopicOf Sterol_regulatory_element-binding_protein.
- Sterol_regulatory_element-binding_protein name "sterol regulatory element-binding transcription factor 1".
- Sterol_regulatory_element-binding_protein name "sterol regulatory element-binding transcription factor 2".
