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- Structural_alignment abstract "Structural alignment attempts to establish homology between two or more polymer structures based on their shape and three-dimensional conformation. This process is usually applied to protein tertiary structures but can also be used for large RNA molecules. In contrast to simple structural superposition, where at least some equivalent residues of the two structures are known, structural alignment requires no a priori knowledge of equivalent positions. Structural alignment is a valuable tool for the comparison of proteins with low sequence similarity, where evolutionary relationships between proteins cannot be easily detected by standard sequence alignment techniques. Structural alignment can therefore be used to imply evolutionary relationships between proteins that share very little common sequence. However, caution should be used in using the results as evidence for shared evolutionary ancestry because of the possible confounding effects of convergent evolution by which multiple unrelated amino acid sequences converge on a common tertiary structure.Structural alignments can compare two sequences or multiple sequences. Because these alignments rely on information about all the query sequences' three-dimensional conformations, the method can only be used on sequences where these structures are known. These are usually found by X-ray crystallography or NMR spectroscopy. It is possible to perform a structural alignment on structures produced by structure prediction methods. Indeed, evaluating such predictions often requires a structural alignment between the model and the true known structure to assess the model's quality. Structural alignments are especially useful in analyzing data from structural genomics and proteomics efforts, and they can be used as comparison points to evaluate alignments produced by purely sequence-based bioinformatics methods.The outputs of a structural alignment are a superposition of the atomic coordinate sets and a minimal root mean square deviation (RMSD) between the structures. The RMSD of two aligned structures indicates their divergence from one another. Structural alignment can be complicated by the existence of multiple protein domains within one or more of the input structures, because changes in relative orientation of the domains between two structures to be aligned can artificially inflate the RMSD.".
- Structural_alignment thumbnail Alignment_of_thioredoxins2.png?width=300.
- Structural_alignment wikiPageExternalLink 2362.
- Structural_alignment wikiPageExternalLink 426?ijkey=oWkOpf10zxhKaF2&keytype=ref.
- Structural_alignment wikiPageExternalLink cl.sdsc.edu.
- Structural_alignment wikiPageExternalLink start.
- Structural_alignment wikiPageExternalLink download.html.
- Structural_alignment wikiPageExternalLink start.
- Structural_alignment wikiPageExternalLink foldalign.kvl.dk.
- Structural_alignment wikiPageExternalLink Structural_alignment_tools.
- Structural_alignment wikiPageExternalLink setter.
- Structural_alignment wikiPageExternalLink SuperPose.
- Structural_alignment wikiPageExternalLink index.html.
- Structural_alignment wikiPageExternalLink explore.do?structureId=1XWC.
- Structural_alignment wikiPageExternalLink explore.do?structureId=3TRX.
- Structural_alignment wikiPageExternalLink workbench.do.
- Structural_alignment wikiPageID "474908".
- Structural_alignment wikiPageRevisionID "594021950".
- Structural_alignment hasPhotoCollection Structural_alignment.
- Structural_alignment subject Category:Protein_methods.
- Structural_alignment type Ability105616246.
- Structural_alignment type Abstraction100002137.
- Structural_alignment type Cognition100023271.
- Structural_alignment type Know-how105616786.
- Structural_alignment type Method105660268.
- Structural_alignment type ProteinMethods.
- Structural_alignment type PsychologicalFeature100023100.
- Structural_alignment comment "Structural alignment attempts to establish homology between two or more polymer structures based on their shape and three-dimensional conformation. This process is usually applied to protein tertiary structures but can also be used for large RNA molecules. In contrast to simple structural superposition, where at least some equivalent residues of the two structures are known, structural alignment requires no a priori knowledge of equivalent positions.".
- Structural_alignment label "Alineamiento estructural".
- Structural_alignment label "Structural alignment".
- Structural_alignment label "Пространственное выравнивание".
- Structural_alignment label "تراصف بنيوي".
- Structural_alignment sameAs Alineamiento_estructural.
- Structural_alignment sameAs m.02dz2m.
- Structural_alignment sameAs Q4116110.
- Structural_alignment sameAs Q4116110.
- Structural_alignment sameAs Structural_alignment.
- Structural_alignment wasDerivedFrom Structural_alignment?oldid=594021950.
- Structural_alignment depiction Alignment_of_thioredoxins2.png.
- Structural_alignment isPrimaryTopicOf Structural_alignment.