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- Structural_biology abstract "Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and how alterations in their structures affect their function. This subject is of great interest to biologists because macromolecules carry out most of the functions of cells, and because it is only by coiling into specific three-dimensional shapes that they are able to perform these functions. This architecture, the "tertiary structure" of molecules, depends in a complicated way on the molecules' basic composition, or "primary structures." Biomolecules are too small to see in detail even with the most advanced light microscopes. The methods that structural biologists use to determine their structures generally involve measurements on vast numbers of identical molecules at the same time. These methods include:Mass spectrometryMacromolecular crystallographyProteolysisNMREPRCryo-electron microscopy (cryo-EM)Multiangle light scatteringSmall angle scatteringUltra fast laser spectroscopyDual Polarisation Interferometry and circular dichroismMost often researchers use them to study the "native states" of macromolecules. But variations on these methods are also used to watch nascent or denatured molecules assume or reassume their native states. See protein folding. A third approach that structural biologists take to understanding structure is bioinformatics to look for patterns among the diverse sequences that give rise to particular shapes. Researchers often can deduce aspects of the structure of integral membrane proteins based on the membrane topology predicted by hydrophobicity analysis. See protein structure prediction. In the past few years it has become possible for highly accurate physical molecular models to complement the in silico study of biological structures.".
- Structural_biology thumbnail Hemoglobin_t-r_state_ani.gif?width=300.
- Structural_biology wikiPageExternalLink structural.shtml.
- Structural_biology wikiPageExternalLink journal-of-structural-biology.
- Structural_biology wikiPageExternalLink nsmb.
- Structural_biology wikiPageExternalLink fetchObjectAttachment.action;jsessionid=CE17B6912F77B4069E4969431710B8A7?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0046147&representation=PDF.
- Structural_biology wikiPageExternalLink www.structuralbiology.eu.
- Structural_biology wikiPageID "29400".
- Structural_biology wikiPageRevisionID "602930176".
- Structural_biology hasPhotoCollection Structural_biology.
- Structural_biology subject Category:Biophysics.
- Structural_biology subject Category:Molecular_biology.
- Structural_biology subject Category:Protein_structure.
- Structural_biology subject Category:Structural_biology.
- Structural_biology comment "Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and how alterations in their structures affect their function.".
- Structural_biology label "Biologia estrutural".
- Structural_biology label "Biologia strukturalna".
- Structural_biology label "Biologia strutturale".
- Structural_biology label "Biologie structurale".
- Structural_biology label "Biología estructural".
- Structural_biology label "Structural biology".
- Structural_biology label "Strukturbiologie".
- Structural_biology label "Структурная биология".
- Structural_biology label "構造生物学".
- Structural_biology label "结构生物学".
- Structural_biology sameAs Strukturbiologie.
- Structural_biology sameAs Biología_estructural.
- Structural_biology sameAs Biologie_structurale.
- Structural_biology sameAs Biologia_strutturale.
- Structural_biology sameAs 構造生物学.
- Structural_biology sameAs 구조생물학.
- Structural_biology sameAs Biologia_strukturalna.
- Structural_biology sameAs Biologia_estrutural.
- Structural_biology sameAs m.078s_.
- Structural_biology sameAs Q908902.
- Structural_biology sameAs Q908902.
- Structural_biology wasDerivedFrom Structural_biology?oldid=602930176.
- Structural_biology depiction Hemoglobin_t-r_state_ani.gif.
- Structural_biology isPrimaryTopicOf Structural_biology.