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- Subplate abstract "The transient fetal subplate zone, together with the marginal zone and the cortical plate, represents the developmental anlage of the mammalian cerebral cortex. It serves as a waiting compartment for growing cortical afferents; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other developmental roles. The subplate zone is a phylogenetically recent structure and it is most developed in the human brain.Subplate neurons are among the first generated neurons in the mammalian cerebral cortex . These neurons disappear during postnatal development and are important in establishing the correct wiring and functional maturation of the cerebral cortex.Subplate neurons appear to be selectively sensitive to injury (such as hypoxia) which in humans are associated with motor and cognitive defects .Subplate neurons are the first cortical neurons to receive synaptic inputs from thalamic axons, establishing a temporary link between thalamic axons and their final target in layer 4. . Later, thalamic axons invade layer 4 where they innervate layer 4 neurons. In the visual system thalamic axons to layer 4 form ocular dominance columns and this segregation of thalamic axons is impaired if subplate neurons are missing .".
- Subplate thumbnail Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.gif?width=300.
- Subplate wikiPageExternalLink pmidlookup?view=long&pmid=19781.
- Subplate wikiPageExternalLink pmidlookup?view=long&pmid=2388080.
- Subplate wikiPageExternalLink pmidlookup?view=long&pmid=12881571.
- Subplate wikiPageExternalLink pmidlookup?view=long&pmid=1542795.
- Subplate wikiPageExternalLink pmidlookup?view=long&pmid=2475909.
- Subplate wikiPageID "4905500".
- Subplate wikiPageRevisionID "593104630".
- Subplate hasPhotoCollection Subplate.
- Subplate subject Category:Central_nervous_system.
- Subplate subject Category:Central_nervous_system_neurons.
- Subplate subject Category:Developmental_neuroscience.
- Subplate subject Category:Nervous_system.
- Subplate type CNSNeurons.
- Subplate type Cell100006484.
- Subplate type LivingThing100004258.
- Subplate type NerveCell105465567.
- Subplate type Object100002684.
- Subplate type PhysicalEntity100001930.
- Subplate type SomaticCell105430628.
- Subplate type Whole100003553.
- Subplate comment "The transient fetal subplate zone, together with the marginal zone and the cortical plate, represents the developmental anlage of the mammalian cerebral cortex. It serves as a waiting compartment for growing cortical afferents; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other developmental roles.".
- Subplate label "Subplate".
- Subplate sameAs m.0cthct.
- Subplate sameAs Q7631811.
- Subplate sameAs Q7631811.
- Subplate sameAs Subplate.
- Subplate wasDerivedFrom Subplate?oldid=593104630.
- Subplate depiction Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.gif.
- Subplate isPrimaryTopicOf Subplate.
