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- Substrate_channeling abstract "Substrate channeling is the passing of the intermediary metabolic product of one enzyme directly to another enzyme or active site without its release into solution. When several consecutive enzymes of a metabolic pathway channel substrates between themselves, this is called a metabolon. Channeling can make a metabolic pathway more rapid and efficient than it would be if the enzymes were randomly distributed in the cytosol, or prevent the release of unstable intermediates. It can also protect an intermediate from being consumed by competing reactions catalyzed by other enzymes.Channeling can occur in several ways. One possibility, which occurs in the pyruvate dehydrogenase complex, is by a substrate being attached to a flexible arm that moves between several active sites. Another possibility is by two active sites being connected by a tunnel through the protein and the substrate moving through the tunnel; this is seen in tryptophan synthase. A third possibility is by a charged region on the surface of the enzyme acting as a pathway or "electrostatic highway" to guide a substrate that has the opposite charge from one active site to another. This is seen in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase. The channeling of aminoacyl-tRNA for protein synthesis in vivo has been also reported.".
- Substrate_channeling wikiPageID "19446142".
- Substrate_channeling wikiPageRevisionID "593104843".
- Substrate_channeling hasPhotoCollection Substrate_channeling.
- Substrate_channeling subject Category:Enzyme_kinetics.
- Substrate_channeling comment "Substrate channeling is the passing of the intermediary metabolic product of one enzyme directly to another enzyme or active site without its release into solution. When several consecutive enzymes of a metabolic pathway channel substrates between themselves, this is called a metabolon. Channeling can make a metabolic pathway more rapid and efficient than it would be if the enzymes were randomly distributed in the cytosol, or prevent the release of unstable intermediates.".
- Substrate_channeling label "Canalización de sustratos".
- Substrate_channeling label "Substrate channeling".
- Substrate_channeling sameAs Canalización_de_sustratos.
- Substrate_channeling sameAs m.04mzlkv.
- Substrate_channeling sameAs Q7632168.
- Substrate_channeling sameAs Q7632168.
- Substrate_channeling wasDerivedFrom Substrate_channeling?oldid=593104843.
- Substrate_channeling isPrimaryTopicOf Substrate_channeling.