Matches in DBpedia 2014 for { <http://dbpedia.org/resource/TAF4> ?p ?o. }
Showing items 1 to 31 of
31
with 100 items per page.
- TAF4 abstract "Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases.".
- TAF4 entrezgene "6874".
- TAF4 symbol "TAF4".
- TAF4 thumbnail PDB_1h3o_EBI.jpg?width=300.
- TAF4 wikiPageExternalLink IEntry?ac=IPR007124.
- TAF4 wikiPageID "14760477".
- TAF4 wikiPageRevisionID "593121647".
- TAF4 caption "crystal structure of the human taf4-taf12 complex".
- TAF4 hasPhotoCollection TAF4.
- TAF4 interpro "IPR007900".
- TAF4 name "TAF4".
- TAF4 pfam "PF05236".
- TAF4 requireManualInspection "no".
- TAF4 scop "1".
- TAF4 summaryText "Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID , which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases.".
- TAF4 symbol "TAF4".
- TAF4 updateCitations "yes".
- TAF4 updatePage "yes".
- TAF4 updateProteinBox "yes".
- TAF4 updateSummary "yes".
- TAF4 type Biomolecule.
- TAF4 type Protein.
- TAF4 type BiologicalObject.
- TAF4 comment "Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.".
- TAF4 label "TAF4".
- TAF4 sameAs m.03gx0f5.
- TAF4 sameAs Q7669236.
- TAF4 sameAs Q7669236.
- TAF4 wasDerivedFrom TAF4?oldid=593121647.
- TAF4 depiction PDB_1h3o_EBI.jpg.
- TAF4 isPrimaryTopicOf TAF4.
