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- TAF6 abstract "Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.".
- TAF6 entrezgene "6878".
- TAF6 wikiPageID "14181259".
- TAF6 wikiPageRevisionID "462164277".
- TAF6 hasPhotoCollection TAF6.
- TAF6 requireManualInspection "no".
- TAF6 summaryText "Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID , which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.".
- TAF6 updateCitations "yes".
- TAF6 updatePage "yes".
- TAF6 updateProteinBox "yes".
- TAF6 updateSummary "yes".
- TAF6 type Biomolecule.
- TAF6 type Protein.
- TAF6 type BiologicalObject.
- TAF6 comment "Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.".
- TAF6 label "TAF6".
- TAF6 sameAs m.03cx2sy.
- TAF6 sameAs Q7669239.
- TAF6 sameAs Q7669239.
- TAF6 wasDerivedFrom TAF6?oldid=462164277.
- TAF6 isPrimaryTopicOf TAF6.