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- TAP2 abstract "TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, schizophrenia, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.".
- TAP2 entrezgene "6891".
- TAP2 wikiPageID "15327936".
- TAP2 wikiPageRevisionID "595425125".
- TAP2 hasPhotoCollection TAP2.
- TAP2 requireManualInspection "no".
- TAP2 summaryText "The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, schizophrenia, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.".
- TAP2 updateCitations "yes".
- TAP2 updatePage "yes".
- TAP2 updateProteinBox "yes".
- TAP2 updateSummary "yes".
- TAP2 subject Category:ABC_transporters.
- TAP2 type Biomolecule.
- TAP2 type Protein.
- TAP2 type BiologicalObject.
- TAP2 comment "TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily.".
- TAP2 label "TAP2".
- TAP2 sameAs m.03m53ny.
- TAP2 sameAs Q7669324.
- TAP2 sameAs Q7669324.
- TAP2 sameAs TAP2.
- TAP2 wasDerivedFrom TAP2?oldid=595425125.
- TAP2 isPrimaryTopicOf TAP2.