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- TOM_complex abstract "The TIM/TOM complex is a process in cellular biochemistry which describes the translocation of proteins produced from nuclear DNA through the mitochondrial membrane for use in oxidative phosphorylation. Only 13 proteins necessary for a mitochondrion are actually coded in mitochondrial DNA.The vast majority of proteins destined for the mitochondria are encoded in the nucleus and synthesized in the cytoplasm. These are tagged by an N-terminal signal sequence. Following transport through the cytosol from the nucleus, the signal sequence is recognized by a receptor protein in the transporter outer membrane (TOM) complex. The signal sequence and adjacent portions of the polypeptide chain are inserted in the TOM complex, then begin interaction with a transporter inner membrane (TIM) complex, which are hypothesized to be transiently linked at sites of close contact between the two membranes. The signal sequence is then translocated into the matrix in a process that requires an electrochemical hydrogen ion gradient across the inner membrane. Mitochondrial Hsp70 binds to regions of the polypeptide chain and maintains it in an unfolded state as it moves into the matrix.".
- TOM_complex wikiPageExternalLink Figure-Pfanner2006.gif.
- TOM_complex wikiPageID "7407236".
- TOM_complex wikiPageRevisionID "602409599".
- TOM_complex hasPhotoCollection TOM_complex.
- TOM_complex subject Category:Mitochondria.
- TOM_complex subject Category:Transmembrane_proteins.
- TOM_complex subject Category:Transport_proteins.
- TOM_complex type Abstraction100002137.
- TOM_complex type Chemical114806838.
- TOM_complex type Compound114818238.
- TOM_complex type Macromolecule114944888.
- TOM_complex type Material114580897.
- TOM_complex type Matter100020827.
- TOM_complex type Molecule114682133.
- TOM_complex type OrganicCompound114727670.
- TOM_complex type Part113809207.
- TOM_complex type PhysicalEntity100001930.
- TOM_complex type Protein114728724.
- TOM_complex type Relation100031921.
- TOM_complex type Substance100019613.
- TOM_complex type Thing100002452.
- TOM_complex type TransmembraneProteins.
- TOM_complex type TransportProteins.
- TOM_complex type Unit109465459.
- TOM_complex comment "The TIM/TOM complex is a process in cellular biochemistry which describes the translocation of proteins produced from nuclear DNA through the mitochondrial membrane for use in oxidative phosphorylation. Only 13 proteins necessary for a mitochondrion are actually coded in mitochondrial DNA.The vast majority of proteins destined for the mitochondria are encoded in the nucleus and synthesized in the cytoplasm. These are tagged by an N-terminal signal sequence.".
- TOM_complex label "TIM/TOM complex".
- TOM_complex sameAs TOM_komplex.
- TOM_complex sameAs m.0260rdm.
- TOM_complex sameAs Q3504639.
- TOM_complex sameAs Q3504639.
- TOM_complex sameAs TOM_complex.
- TOM_complex wasDerivedFrom TOM_complex?oldid=602409599.
- TOM_complex isPrimaryTopicOf TOM_complex.
