Matches in DBpedia 2014 for { <http://dbpedia.org/resource/TIMP2> ?p ?o. }
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- TIMP2 abstract "TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor.This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.In melanocytic cells TIMP2 gene expression may be regulated by MITF.".
- TIMP2 entrezgene "7077".
- TIMP2 wikiPageExternalLink merops.cgi?id=I35.002.
- TIMP2 wikiPageID "14060382".
- TIMP2 wikiPageRevisionID "593194985".
- TIMP2 hasPhotoCollection TIMP2.
- TIMP2 requireManualInspection "no".
- TIMP2 summaryText "This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. In melanocytic cells TIMP2 gene expression may be regulated by MITF.".
- TIMP2 updateCitations "yes".
- TIMP2 updatePage "yes".
- TIMP2 updateProteinBox "yes".
- TIMP2 updateSummary "yes".
- TIMP2 type Biomolecule.
- TIMP2 type Protein.
- TIMP2 type BiologicalObject.
- TIMP2 comment "TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor.This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix.".
- TIMP2 label "TIMP2".
- TIMP2 sameAs m.03csbqx.
- TIMP2 sameAs Q7670420.
- TIMP2 sameAs Q7670420.
- TIMP2 wasDerivedFrom TIMP2?oldid=593194985.
- TIMP2 isPrimaryTopicOf TIMP2.