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- TNK2 abstract "Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene.TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.".
- TNK2 entrezgene "10188".
- TNK2 wikiPageID "14755861".
- TNK2 wikiPageRevisionID "593198264".
- TNK2 hasPhotoCollection TNK2.
- TNK2 requireManualInspection "no".
- TNK2 summaryText "TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor . ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein -stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.".
- TNK2 updateCitations "yes".
- TNK2 updatePage "yes".
- TNK2 updateProteinBox "yes".
- TNK2 updateSummary "yes".
- TNK2 type Biomolecule.
- TNK2 type Protein.
- TNK2 type BiologicalObject.
- TNK2 comment "Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene.TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs.".
- TNK2 label "TNK2".
- TNK2 sameAs m.03gwtxs.
- TNK2 sameAs Q7670873.
- TNK2 sameAs Q7670873.
- TNK2 sameAs 849.
- TNK2 wasDerivedFrom TNK2?oldid=593198264.
- TNK2 isPrimaryTopicOf TNK2.