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- TOP2A abstract "DNA topoisomerase 2-alpha is an enzyme that in humans is encoded by the TOP2A gene.This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.".
- TOP2A entrezgene "7153".
- TOP2A wikiPageID "14058917".
- TOP2A wikiPageRevisionID "593204314".
- TOP2A hasPhotoCollection TOP2A.
- TOP2A requireManualInspection "no".
- TOP2A summaryText "This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.".
- TOP2A updateCitations "yes".
- TOP2A updatePage "yes".
- TOP2A updateProteinBox "yes".
- TOP2A updateSummary "yes".
- TOP2A type Biomolecule.
- TOP2A type Protein.
- TOP2A type BiologicalObject.
- TOP2A comment "DNA topoisomerase 2-alpha is an enzyme that in humans is encoded by the TOP2A gene.This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication.".
- TOP2A label "TOP2A".
- TOP2A label "TOP2A".
- TOP2A sameAs TOP2A.
- TOP2A sameAs m.03cs9w1.
- TOP2A sameAs Q5547557.
- TOP2A sameAs Q5547557.
- TOP2A sameAs TOP2A.
- TOP2A sameAs 817.
- TOP2A wasDerivedFrom TOP2A?oldid=593204314.
- TOP2A isPrimaryTopicOf TOP2A.