Matches in DBpedia 2014 for { <http://dbpedia.org/resource/TOP2B> ?p ?o. }
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- TOP2B abstract "DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents, for example mitoxantrone, and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described.".
- TOP2B entrezgene "7155".
- TOP2B wikiPageID "14138534".
- TOP2B wikiPageRevisionID "593204330".
- TOP2B hasPhotoCollection TOP2B.
- TOP2B requireManualInspection "no".
- TOP2B summaryText "This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents, for example mitoxantrone, and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described.".
- TOP2B updateCitations "yes".
- TOP2B updatePage "yes".
- TOP2B updateProteinBox "yes".
- TOP2B updateSummary "yes".
- TOP2B type Biomolecule.
- TOP2B type Protein.
- TOP2B type BiologicalObject.
- TOP2B comment "DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication.".
- TOP2B label "TOP2B".
- TOP2B label "TOP2B".
- TOP2B sameAs TOP2B.
- TOP2B sameAs m.03cvrr1.
- TOP2B sameAs Q7671013.
- TOP2B sameAs Q7671013.
- TOP2B wasDerivedFrom TOP2B?oldid=593204330.
- TOP2B isPrimaryTopicOf TOP2B.