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- TPH2 abstract "The enzyme Tryptophan hydroxylase 2, also known as TPH2, is an isozyme of Tryptophan hydroxylase found in vertebrates. In humans TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression in the raphe nucleus of the midbrain. Until the discovery of TPH2 in 2003, serotonin levels in the central nervous system were believed to be regulated by serotonin synthesis in peripheral tissues, in which Tryptophan hydroxylase is the dominant form.Tryptophan hydroxylase (TPH; EC 1.14.16.4) is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility.[supplied by OMIM]".
- TPH2 entrezgene "121278".
- TPH2 wikiPageID "14170922".
- TPH2 wikiPageRevisionID "526541329".
- TPH2 hasPhotoCollection TPH2.
- TPH2 requireManualInspection "no".
- TPH2 summaryText "Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin . 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility.[supplied by OMIM]".
- TPH2 updateCitations "yes".
- TPH2 updatePage "yes".
- TPH2 updateProteinBox "yes".
- TPH2 updateSummary "yes".
- TPH2 subject Category:Biology_of_bipolar_disorder.
- TPH2 type Biomolecule.
- TPH2 type Protein.
- TPH2 type BiologicalObject.
- TPH2 comment "The enzyme Tryptophan hydroxylase 2, also known as TPH2, is an isozyme of Tryptophan hydroxylase found in vertebrates. In humans TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression in the raphe nucleus of the midbrain.".
- TPH2 label "TPH2".
- TPH2 sameAs m.03cwrp7.
- TPH2 sameAs Q7671154.
- TPH2 sameAs Q7671154.
- TPH2 sameAs TPH2.
- TPH2 sameAs 90.
- TPH2 wasDerivedFrom TPH2?oldid=526541329.
- TPH2 isPrimaryTopicOf TPH2.