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- TPM1 abstract "Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene.This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.".
- TPM1 entrezgene "7168".
- TPM1 wikiPageExternalLink br.fcgi?book=gene&part=hyper-card.
- TPM1 wikiPageID "14130712".
- TPM1 wikiPageRevisionID "597077991".
- TPM1 hasPhotoCollection TPM1.
- TPM1 requireManualInspection "no".
- TPM1 summaryText "This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.".
- TPM1 updateCitations "yes".
- TPM1 updatePage "yes".
- TPM1 updateProteinBox "yes".
- TPM1 updateSummary "yes".
- TPM1 type Biomolecule.
- TPM1 type Protein.
- TPM1 type BiologicalObject.
- TPM1 comment "Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene.This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments.".
- TPM1 label "TPM1".
- TPM1 sameAs m.03cvj0v.
- TPM1 sameAs Q7671166.
- TPM1 sameAs Q7671166.
- TPM1 sameAs TPM1.
- TPM1 wasDerivedFrom TPM1?oldid=597077991.
- TPM1 isPrimaryTopicOf TPM1.