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- TPSD1 abstract "Tryptase delta is an enzyme that in humans is encoded by the TPSD1 gene.Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.".
- TPSD1 entrezgene "23430".
- TPSD1 wikiPageID "16847969".
- TPSD1 wikiPageRevisionID "593208615".
- TPSD1 hasPhotoCollection TPSD1.
- TPSD1 requireManualInspection "no".
- TPSD1 summaryText "Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.".
- TPSD1 updateCitations "yes".
- TPSD1 updatePage "yes".
- TPSD1 updateProteinBox "yes".
- TPSD1 updateSummary "yes".
- TPSD1 subject Category:EC_3.4.21.
- TPSD1 type Biomolecule.
- TPSD1 type Protein.
- TPSD1 type BiologicalObject.
- TPSD1 comment "Tryptase delta is an enzyme that in humans is encoded by the TPSD1 gene.Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features.".
- TPSD1 label "TPSD1".
- TPSD1 sameAs m.04086m9.
- TPSD1 sameAs Q7671187.
- TPSD1 sameAs Q7671187.
- TPSD1 wasDerivedFrom TPSD1?oldid=593208615.
- TPSD1 isPrimaryTopicOf TPSD1.