Matches in DBpedia 2014 for { <http://dbpedia.org/resource/TRAF2> ?p ?o. }
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- TRAF2 abstract "TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms complexes with other TRAF proteins. TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-κB. The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. cIAP1 can ubiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.".
- TRAF2 entrezgene "7186".
- TRAF2 thumbnail TNF_signaling.jpg?width=300.
- TRAF2 wikiPageID "11627742".
- TRAF2 wikiPageRevisionID "593209453".
- TRAF2 hasPhotoCollection TRAF2.
- TRAF2 requireManualInspection "no".
- TRAF2 summaryText "The protein encoded by this gene is a member of the TNF receptor associated factor protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms complexes with other TRAF proteins. TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-κB. The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. cIAP1 can ubiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.".
- TRAF2 updateCitations "yes".
- TRAF2 updatePage "yes".
- TRAF2 updateProteinBox "yes".
- TRAF2 updateSummary "yes".
- TRAF2 type Biomolecule.
- TRAF2 type Protein.
- TRAF2 type BiologicalObject.
- TRAF2 comment "TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms complexes with other TRAF proteins. TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-κB.".
- TRAF2 label "TRAF2".
- TRAF2 sameAs m.02rly1z.
- TRAF2 sameAs Q7671245.
- TRAF2 sameAs Q7671245.
- TRAF2 wasDerivedFrom TRAF2?oldid=593209453.
- TRAF2 depiction TNF_signaling.jpg.
- TRAF2 isPrimaryTopicOf TRAF2.
