Matches in DBpedia 2014 for { <http://dbpedia.org/resource/TRAF6> ?p ?o. }
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- TRAF6 abstract "TRAF6 is a TRAF human protein.The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/TRANCE/RANKL and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.".
- TRAF6 entrezgene "7189".
- TRAF6 thumbnail Toll-like_receptor_pathways_revised.jpg?width=300.
- TRAF6 wikiPageID "11570541".
- TRAF6 wikiPageRevisionID "602212207".
- TRAF6 hasPhotoCollection TRAF6.
- TRAF6 requireManualInspection "no".
- TRAF6 summaryText "The protein encoded by this gene is a member of the TNF receptor associated factor protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/TRANCE/RANKL and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.".
- TRAF6 updateCitations "yes".
- TRAF6 updatePage "yes".
- TRAF6 updateProteinBox "yes".
- TRAF6 updateSummary "yes".
- TRAF6 type Biomolecule.
- TRAF6 type Protein.
- TRAF6 type BiologicalObject.
- TRAF6 comment "TRAF6 is a TRAF human protein.The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family.".
- TRAF6 label "TRAF6".
- TRAF6 label "TRAF6".
- TRAF6 sameAs m.02rjktf.
- TRAF6 sameAs Q4050614.
- TRAF6 sameAs Q4050614.
- TRAF6 wasDerivedFrom TRAF6?oldid=602212207.
- TRAF6 depiction Toll-like_receptor_pathways_revised.jpg.
- TRAF6 isPrimaryTopicOf TRAF6.
