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- TRH_stimulation_test abstract "Prior to the availability of sensitive TSH assays, thyrotropin releasing hormone (TRH)stimulation tests were relied upon for confirming and assessing the degree of suppressionin suspected hyperthyroidism. Typically, this stimulation test involves determining basalTSH levels and levels 15 to 30 minutes after an intravenous bolus of TRH. Normally,TSH would rise into the concentration range measurable with less sensitive TSH assays.Third generation TSH assays do not have thislimitation and thus TRH stimulation is generally not required when third generation TSHassays are used to assess degree of suppression. TRH-stimulation testing howevercontinues to be useful for the differential diagnosis of secondary (pituitary disorder)and tertiary (hypothalamic disorder) hypothyroidism. Patients with these conditionsappear to have physiologically inactive TSH in their circulation that is recognized byTSH assays to a degree such that they may yield misleading, "euthyroid" TSHresults. Use and Interpretation:• Helpful in diagnosis in patients with confusing TFTs. In primary hyperthyroidismTSH are low and TRH administration induces little or no change in TSH levels• In hypothyroidism due to end organ failure, administration of TRH produces aprompt increase in TSH• In hypothyroidism due to pituitary disease (secondary hypothyroidism)administration of TRH does not producean increase in TSH• In hypothyroidism due to hypothalamic disease (tertiary hypothyroidism), administration of TRH produces adelayed (60-120 minutes, rather than 15-30 minutes) increase in TSH".
- TRH_stimulation_test wikiPageExternalLink endo_thyroidfts.pdf.
- TRH_stimulation_test wikiPageID "22836654".
- TRH_stimulation_test wikiPageRevisionID "561420722".
- TRH_stimulation_test hasPhotoCollection TRH_stimulation_test.
- TRH_stimulation_test subject Category:Blood_tests.
- TRH_stimulation_test type Abstraction100002137.
- TRH_stimulation_test type Act100030358.
- TRH_stimulation_test type Activity100407535.
- TRH_stimulation_test type Assay100791527.
- TRH_stimulation_test type Attempt100786195.
- TRH_stimulation_test type Biopsy105740929.
- TRH_stimulation_test type BloodTest105742551.
- TRH_stimulation_test type BloodTests.
- TRH_stimulation_test type DiagnosticTest105739043.
- TRH_stimulation_test type Event100029378.
- TRH_stimulation_test type PsychologicalFeature100023100.
- TRH_stimulation_test type Test100791078.
- TRH_stimulation_test type YagoPermanentlyLocatedEntity.
- TRH_stimulation_test comment "Prior to the availability of sensitive TSH assays, thyrotropin releasing hormone (TRH)stimulation tests were relied upon for confirming and assessing the degree of suppressionin suspected hyperthyroidism. Typically, this stimulation test involves determining basalTSH levels and levels 15 to 30 minutes after an intravenous bolus of TRH.".
- TRH_stimulation_test label "TRH stimulation test".
- TRH_stimulation_test label "Test TRH".
- TRH_stimulation_test sameAs Test_TRH.
- TRH_stimulation_test sameAs m.06405t7.
- TRH_stimulation_test sameAs Q7671336.
- TRH_stimulation_test sameAs Q7671336.
- TRH_stimulation_test sameAs TRH_stimulation_test.
- TRH_stimulation_test wasDerivedFrom TRH_stimulation_test?oldid=561420722.
- TRH_stimulation_test isPrimaryTopicOf TRH_stimulation_test.