Matches in DBpedia 2014 for { <http://dbpedia.org/resource/TYROBP> ?p ?o. }
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- TYROBP abstract "TYRO protein tyrosine kinase-binding protein is an adapter protein that in humans is encoded by the TYROBP gene.This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined.".
- TYROBP entrezgene "7305".
- TYROBP wikiPageExternalLink br.fcgi?book=gene&part=plosl.
- TYROBP wikiPageID "14177506".
- TYROBP wikiPageRevisionID "606607894".
- TYROBP hasPhotoCollection TYROBP.
- TYROBP requireManualInspection "no".
- TYROBP summaryText "This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain associated protein kinase 70kDa and spleen tyrosine kinase and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy , also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 , also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined.".
- TYROBP updateCitations "yes".
- TYROBP updatePage "yes".
- TYROBP updateProteinBox "yes".
- TYROBP updateSummary "yes".
- TYROBP type Biomolecule.
- TYROBP type Protein.
- TYROBP type BiologicalObject.
- TYROBP comment "TYRO protein tyrosine kinase-binding protein is an adapter protein that in humans is encoded by the TYROBP gene.This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element.".
- TYROBP label "TYROBP".
- TYROBP sameAs m.03cw_r7.
- TYROBP sameAs Q15997240.
- TYROBP sameAs Q15997240.
- TYROBP sameAs TYROBP.
- TYROBP wasDerivedFrom TYROBP?oldid=606607894.
- TYROBP isPrimaryTopicOf TYROBP.