Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Tamoxifen> ?p ?o. }
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- Tamoxifen abstract "Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, 4-hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting.Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.Tamoxifen was discovered by pharmaceutical company Imperial Chemical Industries (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug has been widely referred to by its generic name "tamoxifen", even before its patent expiration.It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.".
- Tamoxifen atcPrefix "L02".
- Tamoxifen atcSuffix "BA01".
- Tamoxifen casNumber "10540-29-1".
- Tamoxifen chEBI "41774".
- Tamoxifen drugbank "DB00675".
- Tamoxifen fdaUniiCode "094ZI81Y45".
- Tamoxifen iupacName "(Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine".
- Tamoxifen pubchem "2733526".
- Tamoxifen thumbnail Tamoxifen2DACS.svg?width=300.
- Tamoxifen wikiPageExternalLink Tamoxifen.
- Tamoxifen wikiPageID "1269557".
- Tamoxifen wikiPageRevisionID "605294679".
- Tamoxifen atcPrefix "L02".
- Tamoxifen atcSuffix "BA01".
- Tamoxifen c "26".
- Tamoxifen casNumber "10540".
- Tamoxifen chebi "41774".
- Tamoxifen chembl "83".
- Tamoxifen chemspiderid "2015313".
- Tamoxifen drugbank "DB00675".
- Tamoxifen eliminationHalfLife "-50400.0".
- Tamoxifen excretion "Faeces , urine".
- Tamoxifen h "29".
- Tamoxifen hasPhotoCollection Tamoxifen.
- Tamoxifen image "Tamoxifen3Dan.gif".
- Tamoxifen inchi "1".
- Tamoxifen inchikey "NKANXQFJJICGDU-QPLCGJKRBF".
- Tamoxifen iupacName "-2".
- Tamoxifen iupharLigand "1016".
- Tamoxifen kegg "D08559".
- Tamoxifen legalAu "S4".
- Tamoxifen legalCa "Rx-only".
- Tamoxifen legalUk "POM".
- Tamoxifen legalUs "Rx-only".
- Tamoxifen medlineplus "a682414".
- Tamoxifen metabolism "Hepatic".
- Tamoxifen molecularWeight "371.515".
- Tamoxifen molecularWeight "563.638".
- Tamoxifen n "1".
- Tamoxifen o "1".
- Tamoxifen pregnancyAu "B3".
- Tamoxifen pregnancyUs "D".
- Tamoxifen proteinBound "99.0".
- Tamoxifen pubchem "2733526".
- Tamoxifen routesOfAdministration "Oral".
- Tamoxifen smiles "OCCNC".
- Tamoxifen stdinchi "1".
- Tamoxifen stdinchikey "NKANXQFJJICGDU-QPLCGJKRSA-N".
- Tamoxifen tradename "Nolvadex, Istubal, Valodex".
- Tamoxifen unii "94".
- Tamoxifen verifiedrevid "470477095".
- Tamoxifen width "200".
- Tamoxifen width "250".
- Tamoxifen subject Category:Alkenes.
- Tamoxifen subject Category:AstraZeneca.
- Tamoxifen subject Category:Chemopreventive_agents.
- Tamoxifen subject Category:Hormonal_antineoplastic_drugs.
- Tamoxifen subject Category:IARC_Group_1_carcinogens.
- Tamoxifen subject Category:Phenol_ethers.
- Tamoxifen subject Category:Prodrugs.
- Tamoxifen subject Category:Selective_estrogen_receptor_modulators.
- Tamoxifen subject Category:Treatment_of_bipolar_disorder.
- Tamoxifen type Drug.
- Tamoxifen type DrugProduct.
- Tamoxifen type FunctionalSubstance.
- Tamoxifen comment "Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, 4-hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist.".
- Tamoxifen label "Tamoksyfen".
- Tamoxifen label "Tamoxifen".
- Tamoxifen label "Tamoxifen".
- Tamoxifen label "Tamoxifen".
- Tamoxifen label "Tamoxifene".
- Tamoxifen label "Tamoxifeno".
- Tamoxifen label "Tamoxifeno".
- Tamoxifen label "Tamoxifène".
- Tamoxifen label "Тамоксифен".
- Tamoxifen label "タモキシフェン".
- Tamoxifen sameAs Tamoxifen.
- Tamoxifen sameAs Tamoxifeno.
- Tamoxifen sameAs Tamoxifène.
- Tamoxifen sameAs Tamoxifene.
- Tamoxifen sameAs タモキシフェン.
- Tamoxifen sameAs Tamoxifen.
- Tamoxifen sameAs Tamoksyfen.
- Tamoxifen sameAs Tamoxifeno.
- Tamoxifen sameAs m.04nv0k.
- Tamoxifen sameAs Q412178.
- Tamoxifen sameAs Q412178.
- Tamoxifen sameAs Tamoxifen.
- Tamoxifen sameAs DB00675.
- Tamoxifen sameAs 5376.
- Tamoxifen wasDerivedFrom Tamoxifen?oldid=605294679.
- Tamoxifen depiction Tamoxifen2DACS.svg.
- Tamoxifen isPrimaryTopicOf Tamoxifen.
