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- Tebanicline abstract "Tebanicline (Ebanicline, ABT-594) is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound.Tebanicline got as far as Phase II trials in humans, but was dropped from further development due to unacceptable incidence of gastrointestinal side effects. However further research in this area is ongoing, and it is expected that development of new neural nicotinic acetylcholine receptor agonists will be likely to lead to novel analgesics suitable for use in humans within the next few years.It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.".
- Tebanicline atcPrefix "none".
- Tebanicline casNumber "198283-73-7".
- Tebanicline fdaUniiCode "9KX8NKV538".
- Tebanicline iupacName "5-([(2R)-Azetidin-2-yl]methoxy)-2-chloropyridine".
- Tebanicline pubchem "3075702".
- Tebanicline thumbnail Tebaniciclina.png?width=300.
- Tebanicline wikiPageID "17712648".
- Tebanicline wikiPageRevisionID "598792819".
- Tebanicline atcPrefix "none".
- Tebanicline c "9".
- Tebanicline casNumber "198283".
- Tebanicline chembl "430497".
- Tebanicline cl "1".
- Tebanicline h "11".
- Tebanicline hasPhotoCollection Tebanicline.
- Tebanicline iupacName "5".
- Tebanicline molecularWeight "198.649".
- Tebanicline n "2".
- Tebanicline o "1".
- Tebanicline pubchem "3075702".
- Tebanicline smiles "C1CN[C@H]1COC2=CN=CCl".
- Tebanicline unii "9".
- Tebanicline verifiedfields "changed".
- Tebanicline verifiedrevid "448113374".
- Tebanicline watchedfields "changed".
- Tebanicline width "240".
- Tebanicline subject Category:Analgesics.
- Tebanicline subject Category:Azetidines.
- Tebanicline subject Category:Nicotinic_agonists.
- Tebanicline subject Category:Organochlorides.
- Tebanicline subject Category:Phenol_ethers.
- Tebanicline subject Category:Pyridines.
- Tebanicline subject Category:Stimulants.
- Tebanicline type Abstraction100002137.
- Tebanicline type Base114618253.
- Tebanicline type Chemical114806838.
- Tebanicline type Cognition100023271.
- Tebanicline type Compound114818238.
- Tebanicline type Element114840755.
- Tebanicline type Information105816287.
- Tebanicline type Material114580897.
- Tebanicline type Matter100020827.
- Tebanicline type Part113809207.
- Tebanicline type PhenolEthers.
- Tebanicline type PhysicalEntity100001930.
- Tebanicline type PsychologicalFeature100023100.
- Tebanicline type Pyridine114692510.
- Tebanicline type Pyridines.
- Tebanicline type Quintessence114847103.
- Tebanicline type Relation100031921.
- Tebanicline type Stimulants.
- Tebanicline type Stimulation105827684.
- Tebanicline type Substance100019613.
- Tebanicline type Drug.
- Tebanicline type DrugProduct.
- Tebanicline type FunctionalSubstance.
- Tebanicline comment "Tebanicline (Ebanicline, ABT-594) is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects.".
- Tebanicline label "Tebaniciclina".
- Tebanicline label "Tebanicline".
- Tebanicline sameAs Tebaniciclina.
- Tebanicline sameAs m.047dv_7.
- Tebanicline sameAs Q7692017.
- Tebanicline sameAs Q7692017.
- Tebanicline sameAs Tebanicline.
- Tebanicline wasDerivedFrom Tebanicline?oldid=598792819.
- Tebanicline depiction Tebaniciclina.png.
- Tebanicline isPrimaryTopicOf Tebanicline.
