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- Tenecteplase abstract "Tenecteplase (TNK) is an enzyme used as a thrombolytic drug.Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in the protease domain.Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modifications at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. Tenecteplase has a higher fibrin specificity and greater resistance to inactivation by its endogenous inhibitor (PAI-1) compared to native t-PA.ResearchResearchers at Newcastle University in Australia say they have had a significant breakthrough in treating stroke patients using the commonly used drug. The findings were published in the New England Medical Journal.Preliminary results show Tenecteplase helps stroke victims. The three-year study was trialled on 75 patients and showed significant improvement with drug use, but more tests will need to be run before the drug is widely used in stroke patients.".
- Tenecteplase atcPrefix "B01".
- Tenecteplase atcSuffix "AD11".
- Tenecteplase casNumber "105857-23-6".
- Tenecteplase drugbank "DB00031".
- Tenecteplase fdaUniiCode "WGD229O42W".
- Tenecteplase iupacName "Human tissue plasminogen activator".
- Tenecteplase wikiPageExternalLink 3905512.
- Tenecteplase wikiPageID "6046521".
- Tenecteplase wikiPageRevisionID "603652058".
- Tenecteplase atcPrefix "B01".
- Tenecteplase atcSuffix "AD11".
- Tenecteplase c "2561".
- Tenecteplase casNumber "105857".
- Tenecteplase chemspiderid "NA".
- Tenecteplase drugbank "DB00031".
- Tenecteplase excretion "Liver".
- Tenecteplase h "3919".
- Tenecteplase hasPhotoCollection Tenecteplase.
- Tenecteplase iupacName "Human tissue plasminogen activator".
- Tenecteplase kegg "D02837".
- Tenecteplase legalStatus "Rx".
- Tenecteplase molecularWeight "58951.2".
- Tenecteplase n "747".
- Tenecteplase o "781".
- Tenecteplase s "40".
- Tenecteplase tradename "Tnkase".
- Tenecteplase unii "WGD229O42W".
- Tenecteplase verifiedrevid "477861633".
- Tenecteplase subject Category:Antithrombotic_enzymes.
- Tenecteplase type Abstraction100002137.
- Tenecteplase type Activator114723079.
- Tenecteplase type AntithromboticEnzymes.
- Tenecteplase type Catalyst114723628.
- Tenecteplase type Chemical114806838.
- Tenecteplase type Compound114818238.
- Tenecteplase type Enzyme114732946.
- Tenecteplase type Macromolecule114944888.
- Tenecteplase type Material114580897.
- Tenecteplase type Matter100020827.
- Tenecteplase type Molecule114682133.
- Tenecteplase type OrganicCompound114727670.
- Tenecteplase type Part113809207.
- Tenecteplase type PhysicalEntity100001930.
- Tenecteplase type Protein114728724.
- Tenecteplase type Relation100031921.
- Tenecteplase type Substance100019613.
- Tenecteplase type Thing100002452.
- Tenecteplase type Unit109465459.
- Tenecteplase type Drug.
- Tenecteplase type DrugProduct.
- Tenecteplase type FunctionalSubstance.
- Tenecteplase comment "Tenecteplase (TNK) is an enzyme used as a thrombolytic drug.Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells).".
- Tenecteplase label "Tenecteplase".
- Tenecteplase label "Tenecteplase".
- Tenecteplase label "Tenecteplase".
- Tenecteplase label "Тенектеплаза".
- Tenecteplase sameAs Tenecteplase.
- Tenecteplase sameAs Tenecteplase.
- Tenecteplase sameAs m.0fmc7w.
- Tenecteplase sameAs Q1644947.
- Tenecteplase sameAs Q1644947.
- Tenecteplase sameAs Tenecteplase.
- Tenecteplase sameAs DB00031.
- Tenecteplase sameAs Tenecteplase.
- Tenecteplase wasDerivedFrom Tenecteplase?oldid=603652058.
- Tenecteplase isPrimaryTopicOf Tenecteplase.