Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Thebacon> ?p ?o. }
Showing items 1 to 67 of
67
with 100 items per page.
- Thebacon abstract "Thebacon (INN; pronounced /ˈθiːbəkɒn/), or dihydrocodeinone enol acetate, is a semisynthetic opioid that is similar to hydrocodone and is most commonly synthesised from thebaine. Thebacon is a very close relative derivat of Acetyldihydrocodeine, where only the 6-7 double bond is saturated. Thebacon is marketed as its hydrochloride salt under the trade name Acedicon and as the bitartrate as Diacodin and other trade names. The hydrochloride salt has a free base conversion ratio of 0.846. Other salts used in research and other settings include the phosphate, hydrobromide, citrate, hydroiodide, and sulphate. The US DEA Administrative Controlled Substance Control Number assigned by the Controlled Substances Act 1970 for thebacon and all of its salts is 9737.Thebacon it is an opioid agonist narcotic analgesic of the middle range and a strong antitussive, primarily used in Europe, although it is no longer in common use. Currently dihydrocodeine and nicocodeine are used as second-line codeine replacements. It was invented in Germany in 1924 four years after the first synthesis of hydrocodone. The other dihydromorphinone used as an antitussive is hydromorphone (Dilaudid Cough Syrup); the other narcotic antitussives are either more directly related to codeine or not so at all (open chain methadone relatives and thiambutenes).Thebacon is indicated for moderate to moderately severe pain and dry painful coughing just as is hydrocodone. It has a duration of action in the range of 5 to 9 hours and doses typically start at 5 mg q6h. The drug is most commonly taken orally as an elixir, tablet, or capsule although rectal and subcutaneous administration have the advantages they do with hydrocodone as would taking a tablet or powder or a liquid concentrate bucally or sublingually.Thebacon is generated by the esterification product of the enol tautomer of hydrocodone (dihydrocodeineone) with acetic acid. Although modification of thebaine is the most common way of making thebacon, it is not uncommonly prepared by refluxing hydrocodone with acetic anhydride, generally similar to how diacetylmorphine is produced. It also is a product of the metabolism of hydrocodone by Pseudomonas putida M10, the bacterium used for oil spill remediation which also produces a morphinone reductase which can turn morphine into hydromorphone in a process which produces other active opioids such as oxymorphone, oxymorphol, hydromorphinol as intermediates.Thebacon's analgesic and antitussive potency is slightly higher than that of its parent compound hydrocodone which makes it approximately eight times the milligramme strength of codeine. The acetylation at position 3 and the conversion into a dihydromorphinone class semisynthetic (at position 14 on the morphine carbon skeleton) allows for the drug to more rapidly enter the central nervous system in greater quantity where it is de-acetylated into hydromorphone, and also converted by other processes into hydromorphinol, morphine and various other active and inactive substances; it therefore simultaneously takes advantage of two methods of increasing the effectiveness of morphine and its derivatives, those being catalytic hydrogenation (codeine into hydrocodone) and esterification (morphine into diamorphine, nicomorphine &c) in a manner not unlike to that of dihydrodiacetylmorphine.Like all of its chemical relatives in this class (codeine-based semi-synthetic narcotic antitussives), thebacon exerts its analgesic effect and a large part of its antitussive and antiperistaltic action as a prodrug for stronger and/or longer-lasting opioids, primarily hydromorphone, which is formed in the liver by the cytochrome P450 2D6 (CYP2D6) enzyme pathway as well as acetylmorphone. As a result, the effectiveness of a given dose of thebacon will vary amongst patients and some food and drugs can affect various parts of the liberation, absorption, distribution, metabolism and elimination profile and therefore a variable proportion of the potency of thebacon. Thebacon can be said to be the 3-monoacetylmorphine analog of hydrocodone, and/or the acetylmorphone analog of codeine. It is also a close structural relative of 3,14-diacetyloxymorphone. For both pain and coughing, thebacon can be made more effective along with Nsaids, muscle relaxants, and/or antihistamines like tripelennamine, hydroxyzine, promethazine, phenyltoloxamine and chlorpheniramine.Thebacon is a Schedule I controlled substance in the US, never having been in medical use there.".
- Thebacon atcPrefix "R05".
- Thebacon atcSuffix "DA10".
- Thebacon casNumber "466-90-0".
- Thebacon fdaUniiCode "520D430GDK".
- Thebacon iupacName "6,7-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6-ol acetate".
- Thebacon pubchem "10075".
- Thebacon thumbnail Thebacon_structure.svg?width=300.
- Thebacon wikiPageID "8803556".
- Thebacon wikiPageRevisionID "602724437".
- Thebacon atcPrefix "R05".
- Thebacon atcSuffix "DA10".
- Thebacon c "20".
- Thebacon casNumber "466".
- Thebacon chembl "2104751".
- Thebacon h "23".
- Thebacon hasPhotoCollection Thebacon.
- Thebacon iupacName "67".
- Thebacon kegg "D07386".
- Thebacon legalAu "S8".
- Thebacon legalUs "Schedule I".
- Thebacon molecularWeight "341.401".
- Thebacon n "1".
- Thebacon o "4".
- Thebacon pubchem "10075".
- Thebacon unii "520".
- Thebacon verifiedfields "changed".
- Thebacon verifiedrevid "447722161".
- Thebacon watchedfields "changed".
- Thebacon subject Category:Acetate_esters.
- Thebacon subject Category:Morphinans.
- Thebacon subject Category:Mu-opioid_agonists.
- Thebacon subject Category:Phenol_ethers.
- Thebacon subject Category:Semisynthetic_opioids.
- Thebacon type Abstraction100002137.
- Thebacon type AcetateEsters.
- Thebacon type Chemical114806838.
- Thebacon type Compound114818238.
- Thebacon type Element114840755.
- Thebacon type Ester114850483.
- Thebacon type Material114580897.
- Thebacon type Matter100020827.
- Thebacon type OrganicCompound114727670.
- Thebacon type Part113809207.
- Thebacon type PhenolEthers.
- Thebacon type PhysicalEntity100001930.
- Thebacon type Quintessence114847103.
- Thebacon type Relation100031921.
- Thebacon type Substance100019613.
- Thebacon type Drug.
- Thebacon type DrugProduct.
- Thebacon type FunctionalSubstance.
- Thebacon comment "Thebacon (INN; pronounced /ˈθiːbəkɒn/), or dihydrocodeinone enol acetate, is a semisynthetic opioid that is similar to hydrocodone and is most commonly synthesised from thebaine. Thebacon is a very close relative derivat of Acetyldihydrocodeine, where only the 6-7 double bond is saturated. Thebacon is marketed as its hydrochloride salt under the trade name Acedicon and as the bitartrate as Diacodin and other trade names. The hydrochloride salt has a free base conversion ratio of 0.846.".
- Thebacon label "Tebakon".
- Thebacon label "Thebacon".
- Thebacon label "Thebacon".
- Thebacon label "Thebacon".
- Thebacon sameAs Thebacon.
- Thebacon sameAs Thebacon.
- Thebacon sameAs Tebakon.
- Thebacon sameAs m.027k851.
- Thebacon sameAs Q2787672.
- Thebacon sameAs Q2787672.
- Thebacon sameAs Thebacon.
- Thebacon wasDerivedFrom Thebacon?oldid=602724437.
- Thebacon depiction Thebacon_structure.svg.
- Thebacon isPrimaryTopicOf Thebacon.