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- Thioflavin abstract "Thioflavin can refer to either of two dyes used for histology staining and biophysical studies of protein aggregation.Thioflavin T (Basic Yellow 1 or CI 49005) is a benzothiazole salt obtained by the methylation of dehydrothiotoluidine with methanol in the presence of hydrochloric acid. The dye is widely used to visualize and quantify the presence of misfolded protein aggregates called amyloid, both in vitro and in vivo (e.g., plaques composed of amyloid beta found in the brains of Alzheimer's disease patients).When it binds to beta sheet-rich structures, such as those in amyloid aggregates, the dye displays enhanced fluorescence and a characteristic red shift of its emission spectrum. This change in fluorescent behavior can be caused by many factors that affect the excited state charge distribution of Thioflavin T, including binding to a rigid, highly-ordered amyloid structure, or to specific chemical interactions with a protein.Thioflavin T fluorescence is often used as a diagnostic of amyloid structure, but it is not perfectly specific for amyloid. Depending on the particular protein and experimental conditions, Thioflavin T may or may not undergo a spectroscopic change upon binding to precursor monomers, small oligomers, unaggregated material with a high beta sheet content, or even alpha helix-rich proteins. Conversely, some amyloid fibers do not affect Thioflavin T fluorescence, raising the prospect of false negative results.An article published online in Nature on 30 March 2011 showed that Thioflavin T exposure on adult C. elegans resulted "in a profoundly extended lifespan and slowed aging" at some levels, but decreased lifespan at higher levels.Thioflavin S is a homogenous mixture of compounds that results from the methylation of dehydrothiotoluidine with sulfonic acid. It is also used to stain amyloid plaques. Like Thioflavin T it binds to amyloid fibrils but not monomers and gives a distinct increase in fluorescence emission. However unlike Thioflavin T, it does not produce a characteristic shift in the excitation or emission spectra. This latter characteristic of Thioflavin S results in high background fluorescence, making it unable to be used in quantitative measurements of fibril solutions. Another dye that is used to identify amyloid structure is Congo Red.".
- Thioflavin iupacName "-ium-2-yl)-N,N-dimethylaniline chloride".
- Thioflavin iupacName "4-(3,6-dimethyl-1,3-benzothiazol-3".
- Thioflavin thumbnail Thioflavin_T.png?width=300.
- Thioflavin wikiPageID "3615953".
- Thioflavin wikiPageRevisionID "585861348".
- Thioflavin hasPhotoCollection Thioflavin.
- Thioflavin imagefile "Thioflavin T.png".
- Thioflavin imagefile "Thioflavin-T-3D-balls.png".
- Thioflavin imagesize "200".
- Thioflavin iupacname "4".
- Thioflavin name "Thioflavin T".
- Thioflavin verifiedfields "changed".
- Thioflavin verifiedrevid "477863380".
- Thioflavin subject Category:Benzothiazoles.
- Thioflavin subject Category:Quaternary_ammonium_compounds.
- Thioflavin subject Category:Thiazole_dyes.
- Thioflavin type Abstraction100002137.
- Thioflavin type Chemical114806838.
- Thioflavin type ColoringMaterial114984973.
- Thioflavin type Compound114818238.
- Thioflavin type Dye114985383.
- Thioflavin type Material114580897.
- Thioflavin type Matter100020827.
- Thioflavin type OrganicCompound114727670.
- Thioflavin type Part113809207.
- Thioflavin type PhysicalEntity100001930.
- Thioflavin type QuaternaryAmmoniumCompound114691231.
- Thioflavin type QuaternaryAmmoniumCompounds.
- Thioflavin type Relation100031921.
- Thioflavin type Substance100019613.
- Thioflavin type ThiazoleDyes.
- Thioflavin type ChemicalCompound.
- Thioflavin type ChemicalSubstance.
- Thioflavin type ChemicalSubstanceType.
- Thioflavin type ChemicalObject.
- Thioflavin type Thing.
- Thioflavin comment "Thioflavin can refer to either of two dyes used for histology staining and biophysical studies of protein aggregation.Thioflavin T (Basic Yellow 1 or CI 49005) is a benzothiazole salt obtained by the methylation of dehydrothiotoluidine with methanol in the presence of hydrochloric acid.".
- Thioflavin label "Thioflavin".
- Thioflavin label "Тиофлавин T".
- Thioflavin sameAs m.09q41m.
- Thioflavin sameAs Q2033625.
- Thioflavin sameAs Q2033625.
- Thioflavin sameAs Thioflavin.
- Thioflavin wasDerivedFrom Thioflavin?oldid=585861348.
- Thioflavin depiction Thioflavin_T.png.
- Thioflavin isPrimaryTopicOf Thioflavin.
- Thioflavin name "Thioflavin T".
