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Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Thrombotic_thrombocytopenic_purpura> ?p ?o. }

• Thrombotic_thrombocytopenic_purpura abstract "Thrombotic thrombocytopenic purpura (TTP or Moschcowitz syndrome) is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body. These small blood clots, called thrombi, can damage many organs including the kidneys, heart and brain. In the era before effective treatment with plasma exchange, the fatality rate was about 90%. With plasma exchange, this has dropped to 10% at six months. Immunosuppressants, such as glucocorticoids, rituximab, cyclophosphamide, vincristine, or cyclosporine, may also be used if a relapse or recurrence follows plasma exchange.Most cases of TTP arise from inhibition of the enzyme ADAMTS13, a metalloprotease responsible for cleaving large multimers of von Willebrand factor (vWF) into smaller units. The increase in circulating multimers of vWF increase platelet adhesion to areas of endothelial injury, particularly at arteriole-capillary junctions. A rarer form of TTP, called Upshaw-Schülman syndrome, is genetically inherited as a dysfunction of ADAMTS13. If large vWF multimers persist, a tendency for increased coagulation exists.Red blood cells passing the microscopic clots are subjected to shear stress which damages their membranes, leading to intravascular hemolysis, which in turn leads to anaemia and schistocyte formation. Reduced blood flow due to thrombosis and cellular injury results in end organ damage. Current therapy is based on support and plasmapheresis to reduce circulating antibodies against ADAMTS13 and replenish blood levels of the enzyme.".
• Thrombotic_thrombocytopenic_purpura diseasesdb "13052".
• Thrombotic_thrombocytopenic_purpura emedicineSubject "emerg".
• Thrombotic_thrombocytopenic_purpura emedicineTopic "579".
• Thrombotic_thrombocytopenic_purpura icd10 "M31.1 (ILDS M31.110)".
• Thrombotic_thrombocytopenic_purpura icd9 "446.6".
• Thrombotic_thrombocytopenic_purpura medlineplus "000552".
• Thrombotic_thrombocytopenic_purpura meshId "D011697".
• Thrombotic_thrombocytopenic_purpura omim "274150".
• Thrombotic_thrombocytopenic_purpura thumbnail Acute_thrombotic_microangiopathy_-_very_high_mag.jpg?width=300.
• Thrombotic_thrombocytopenic_purpura wikiPageID "472537".
• Thrombotic_thrombocytopenic_purpura wikiPageRevisionID "606776332".
• Thrombotic_thrombocytopenic_purpura caption "Micrograph showing an acute thrombotic microangiopathy, as may be seen in TTP. A thrombus is present in the hilum of the glomerulus . Kidney biopsy. H&E stain.".
• Thrombotic_thrombocytopenic_purpura diseasesdb "13052".
• Thrombotic_thrombocytopenic_purpura emedicinesubj "emerg".
• Thrombotic_thrombocytopenic_purpura emedicinetopic "579".
• Thrombotic_thrombocytopenic_purpura hasPhotoCollection Thrombotic_thrombocytopenic_purpura.
• Thrombotic_thrombocytopenic_purpura icd "446.6".
• Thrombotic_thrombocytopenic_purpura icd "M31.1".
• Thrombotic_thrombocytopenic_purpura medlineplus "552".
• Thrombotic_thrombocytopenic_purpura meshid "D011697".
• Thrombotic_thrombocytopenic_purpura name "Thrombotic thrombocytopenic purpura".
• Thrombotic_thrombocytopenic_purpura omim "274150".
• Thrombotic_thrombocytopenic_purpura wordnet_type synset-disease-noun-1.
• Thrombotic_thrombocytopenic_purpura subject Category:Autoimmune_diseases.
• Thrombotic_thrombocytopenic_purpura subject Category:Coagulopathies.
• Thrombotic_thrombocytopenic_purpura subject Category:Rare_diseases.
• Thrombotic_thrombocytopenic_purpura subject Category:Vascular-related_cutaneous_conditions.
• Thrombotic_thrombocytopenic_purpura type Abstraction100002137.
• Thrombotic_thrombocytopenic_purpura type Attribute100024264.
• Thrombotic_thrombocytopenic_purpura type Condition113920835.
• Thrombotic_thrombocytopenic_purpura type Disease114070360.
• Thrombotic_thrombocytopenic_purpura type IllHealth114052046.
• Thrombotic_thrombocytopenic_purpura type Illness114061805.
• Thrombotic_thrombocytopenic_purpura type PathologicalState114051917.
• Thrombotic_thrombocytopenic_purpura type PhysicalCondition114034177.
• Thrombotic_thrombocytopenic_purpura type State100024720.
• Thrombotic_thrombocytopenic_purpura type Vascular-relatedCutaneousConditions.
• Thrombotic_thrombocytopenic_purpura type Disease.
• Thrombotic_thrombocytopenic_purpura type AilmentCondition.
• Thrombotic_thrombocytopenic_purpura type Situation.
• Thrombotic_thrombocytopenic_purpura comment "Thrombotic thrombocytopenic purpura (TTP or Moschcowitz syndrome) is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body. These small blood clots, called thrombi, can damage many organs including the kidneys, heart and brain. In the era before effective treatment with plasma exchange, the fatality rate was about 90%. With plasma exchange, this has dropped to 10% at six months.".
• Thrombotic_thrombocytopenic_purpura label "Porpora trombotica trombocitopenica".
• Thrombotic_thrombocytopenic_purpura label "Purpura thrombotique thrombocytopénique".
• Thrombotic_thrombocytopenic_purpura label "Púrpura trombocitopénica trombótica".
• Thrombotic_thrombocytopenic_purpura label "Púrpura trombocitopênica trombótica".
• Thrombotic_thrombocytopenic_purpura label "Thrombotic thrombocytopenic purpura".
• Thrombotic_thrombocytopenic_purpura label "Thrombotisch-thrombozytopenische Purpura".
• Thrombotic_thrombocytopenic_purpura label "Trombotische trombocytopenische purpura".
• Thrombotic_thrombocytopenic_purpura label "Zakrzepowa plamica małopłytkowa".
• Thrombotic_thrombocytopenic_purpura label "血栓性血小板減少性紫斑病".
• Thrombotic_thrombocytopenic_purpura sameAs Thrombotisch-thrombozytopenische_Purpura.
• Thrombotic_thrombocytopenic_purpura sameAs Púrpura_trombocitopénica_trombótica.
• Thrombotic_thrombocytopenic_purpura sameAs Purpura_thrombotique_thrombocytopénique.
• Thrombotic_thrombocytopenic_purpura sameAs Porpora_trombotica_trombocitopenica.
• Thrombotic_thrombocytopenic_purpura sameAs 血栓性血小板減少性紫斑病.
• Thrombotic_thrombocytopenic_purpura sameAs Trombotische_trombocytopenische_purpura.
• Thrombotic_thrombocytopenic_purpura sameAs Zakrzepowa_plamica_małopłytkowa.
• Thrombotic_thrombocytopenic_purpura sameAs Púrpura_trombocitopênica_trombótica.
• Thrombotic_thrombocytopenic_purpura sameAs m.02dp3g.
• Thrombotic_thrombocytopenic_purpura sameAs Q1426491.
• Thrombotic_thrombocytopenic_purpura sameAs Q1426491.
• Thrombotic_thrombocytopenic_purpura sameAs C0034155.
• Thrombotic_thrombocytopenic_purpura sameAs Thrombotic_thrombocytopenic_purpura.
• Thrombotic_thrombocytopenic_purpura wasDerivedFrom Thrombotic_thrombocytopenic_purpura?oldid=606776332.
• Thrombotic_thrombocytopenic_purpura depiction Acute_thrombotic_microangiopathy_-_very_high_mag.jpg.
• Thrombotic_thrombocytopenic_purpura isPrimaryTopicOf Thrombotic_thrombocytopenic_purpura.
• Thrombotic_thrombocytopenic_purpura name "Thrombotic thrombocytopenic purpura".