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- Thymus abstract "The thymus is a specialized organ of the immune system. Within the thymus, T-cells, critical to the adaptive immune system, mature.Each T cell attacks a foreign substance which it identifies with its receptor. T cells have receptors which are generated by randomly shuffling gene segments. Each T cell attacks a different antigen. T cells that attack the body's own proteins are eliminated in the thymus. Thymic epithelial cells express major proteins from elsewhere in the body. First, T cells undergo "Positive Selection" whereby the cell comes in contact with self-MHC expressed by thymic epithelial cells; those with no interaction are destroyed. Second, the T cell undergoes "Negative Selection" by interacting with thymic dendritic cell whereby T cells with high affinity interaction are eliminated through apoptosis (to avoid autoimmunity), and those with intermediate affinity survive.The thymus is composed of two identical lobes and is located anatomically in the anterior superior mediastinum, in front of the heart and behind the sternum.Histologically, each lobe of the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T-cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin (derived from bone marrow resident hematopoietic stem cells). Developing T-cells are referred to as thymocytes and are of hematopoietic origin. Stromal cells include thymic cortical epithelial cells, thymic medullary epithelial cells, and dendritic cells.The thymus provides an inductive environment for development of T-lymphocytes from hematopoietic progenitor cells. In addition, thymic stromal cells allow for the selection of a functional and self-tolerant T-cell repertoire. Therefore, one of the most important roles of the thymus is the induction of central tolerance.The thymus is largest and most active during the neonatal and pre-adolescent periods. By the early teens, the thymus begins to atrophy and thymic stroma is mostly replaced by adipose (fat) tissue. Nevertheless, residual T lymphopoiesis continues throughout adult life.".
- Thymus grayPage "1273".
- Thymus graySubject "274".
- Thymus meshName "Thymus+gland".
- Thymus meshNumber "A10.549.750".
- Thymus thumbnail Illu_thymus.jpg?width=300.
- Thymus wikiPageID "56265".
- Thymus wikiPageRevisionID "604262062".
- Thymus caption "Thymus".
- Thymus dorlands "eight/000108702".
- Thymus dorlandsid "Thymus".
- Thymus graypage "1273".
- Thymus graysubject "274".
- Thymus hasPhotoCollection Thymus.
- Thymus image2Lymph Parasternal_lymph_nodes.
- Thymus image2Lymph Tracheobronchial_lymph_nodes.
- Thymus latin "Thymus".
- Thymus meshname "Thymus+gland".
- Thymus meshnumber "A10.549.750".
- Thymus name "Thymus".
- Thymus wordnet_type synset-human_body-noun-1.
- Thymus subject Category:Immune_system.
- Thymus subject Category:Lymphatic_system.
- Thymus subject Category:Lymphatics_of_the_torso.
- Thymus subject Category:Lymphoid_organ.
- Thymus subject Category:Organs.
- Thymus subject Category:Thymus.
- Thymus type Abstraction100002137.
- Thymus type Anatomy106057539.
- Thymus type Biology106037666.
- Thymus type Cognition100023271.
- Thymus type Content105809192.
- Thymus type Discipline105996646.
- Thymus type KnowledgeDomain105999266.
- Thymus type LifeScience106037298.
- Thymus type Morphology106078327.
- Thymus type NaturalScience106000400.
- Thymus type PsychologicalFeature100023100.
- Thymus type Science105999797.
- Thymus type AnatomicalStructure.
- Thymus type AnimalBodyPart.
- Thymus type BiologicalObject.
- Thymus comment "The thymus is a specialized organ of the immune system. Within the thymus, T-cells, critical to the adaptive immune system, mature.Each T cell attacks a foreign substance which it identifies with its receptor. T cells have receptors which are generated by randomly shuffling gene segments. Each T cell attacks a different antigen. T cells that attack the body's own proteins are eliminated in the thymus. Thymic epithelial cells express major proteins from elsewhere in the body.".
- Thymus label "Grasica".
- Thymus label "Thymus (anatomie)".
- Thymus label "Thymus (orgaan)".
- Thymus label "Thymus".
- Thymus label "Thymus".
- Thymus label "Timo (anatomia)".
- Thymus label "Timo".
- Thymus label "Timo".
- Thymus label "Тимус".
- Thymus label "الغدة الزغترية".
- Thymus label "胸腺".
- Thymus label "胸腺".
- Thymus sameAs Brzlík.
- Thymus sameAs Thymus.
- Thymus sameAs Θύμος_αδένας.
- Thymus sameAs Timo.
- Thymus sameAs Timo.
- Thymus sameAs Thymus_(anatomie).
- Thymus sameAs Timus.
- Thymus sameAs Timo_(anatomia).
- Thymus sameAs 胸腺.
- Thymus sameAs 흉선.
- Thymus sameAs Thymus_(orgaan).
- Thymus sameAs Grasica.
- Thymus sameAs Timo.
- Thymus sameAs m.0fl12.
- Thymus sameAs Q163987.
- Thymus sameAs Q163987.
- Thymus sameAs Thymus.
- Thymus wasDerivedFrom Thymus?oldid=604262062.
- Thymus depiction Illu_thymus.jpg.
- Thymus isPrimaryTopicOf Thymus.
- Thymus name "Thymus".
