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- Tipifarnib abstract "Tipifarnib (trade name Zarnestra) is a farnesyltransferase inhibitor that is being investigated in patients 65 years of age and older with newly diagnosed acute myeloid leukemia (AML). It inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive. It inhibits prenylation of the CxxX tail motif, which allows Ras to bind to the membrane where it is active. Without this step the protein cannot function.It is also being tested in clinical trials in patients in certain stages of breast cancer.For treatment of progressive plexiform neurofibromas associated with Neurofibromatosis type I, it successfully passed phase one clinical trials but was suspended (NCT00029354) in phase two.The compound was discovered by and is under investigation by Johnson & Johnson Pharmaceutical Research & Development, L.L.C, with registration number R115777.".
- Tipifarnib atcPrefix "none".
- Tipifarnib fdaUniiCode "MAT637500A".
- Tipifarnib iupacName "6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one".
- Tipifarnib pubchem "148193".
- Tipifarnib thumbnail Tipifarnib.png?width=300.
- Tipifarnib wikiPageID "6806262".
- Tipifarnib wikiPageRevisionID "503024344".
- Tipifarnib atcPrefix "none".
- Tipifarnib c "27".
- Tipifarnib chembl "289228".
- Tipifarnib cl "2".
- Tipifarnib h "22".
- Tipifarnib hasPhotoCollection Tipifarnib.
- Tipifarnib iupacName "6".
- Tipifarnib molecularWeight "489.395".
- Tipifarnib n "4".
- Tipifarnib o "1".
- Tipifarnib pubchem "148193".
- Tipifarnib unii "MAT637500A".
- Tipifarnib verifiedfields "changed".
- Tipifarnib verifiedrevid "376279232".
- Tipifarnib subject Category:Farnesyltransferase_inhibitors.
- Tipifarnib subject Category:Imidazoles.
- Tipifarnib type Abstraction100002137.
- Tipifarnib type Base114618253.
- Tipifarnib type Chemical114806838.
- Tipifarnib type Compound114818238.
- Tipifarnib type Imidazole114916670.
- Tipifarnib type Imidazoles.
- Tipifarnib type Material114580897.
- Tipifarnib type Matter100020827.
- Tipifarnib type Part113809207.
- Tipifarnib type PhysicalEntity100001930.
- Tipifarnib type Relation100031921.
- Tipifarnib type Substance100019613.
- Tipifarnib type Drug.
- Tipifarnib type DrugProduct.
- Tipifarnib type FunctionalSubstance.
- Tipifarnib comment "Tipifarnib (trade name Zarnestra) is a farnesyltransferase inhibitor that is being investigated in patients 65 years of age and older with newly diagnosed acute myeloid leukemia (AML). It inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive. It inhibits prenylation of the CxxX tail motif, which allows Ras to bind to the membrane where it is active.".
- Tipifarnib label "Tipifarnib".
- Tipifarnib sameAs m.0gpw9k.
- Tipifarnib sameAs Q7808830.
- Tipifarnib sameAs Q7808830.
- Tipifarnib sameAs Tipifarnib.
- Tipifarnib wasDerivedFrom Tipifarnib?oldid=503024344.
- Tipifarnib depiction Tipifarnib.png.
- Tipifarnib isPrimaryTopicOf Tipifarnib.
