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- Toxicogenomics abstract "Toxicogenomics is a field of science that deals with the collection, interpretation, and storage of information about gene and protein activity within particular cell or tissue of an organism in response to toxic substances. Toxicogenomics combines toxicology with genomics or other high throughput molecular profiling technologies such as transcriptomics, proteomics and metabolomics. Toxicogenomics endeavors to elucidate molecular mechanisms evolved in the expression of toxicity, and to derive molecular expression patterns (i.e., molecular biomarkers) that predict toxicity or the genetic susceptibility to it.In pharmaceutical research toxicogenomics is defined as the study of the structure and function of the genome as it responds to adverse xenobiotic exposure. It is the toxicological subdiscipline of pharmacogenomics, which is broadly defined as the study of inter-individual variations in whole-genome or candidate gene single-nucleotide polymorphism maps, haplotype markers, and alterations in gene expression that might correlate with drug responses (Lesko and Woodcock 2004, Lesko et al. 2003). Though the term toxicogenomics first appeared in the literature in 1999 (Nuwaysir et al.) it was already in common use within the pharmaceutical industry as its origin was driven by marketing strategies from vendor companies. The term is still not universal accepted, and others have offered alternative terms such as chemogenomics to describe essentially the same area (Fielden et al., 2005). The nature and complexity of the data (in volume and variability) demands highly developed processes of automated handling and storage. The analysis usually involves a wide array of bioinformatics and statistics, regularly involving classification approaches.In pharmaceutical drug discovery and development toxicogenomics is used to study adverse, i.e. toxic, effects, of pharmaceutical drugs in defined model systems in order to draw conclusions on the toxic risk to patients or the environment.Both the EPA and the U.S. Food and Drug Administration currently preclude basing regulatory decision making on genomics data alone. However, they do encourage the voluntary submission of well-documented, quality genomics data. Both agencies are considering the use of submitted data on a case-by-case basis for assessment purposes (e.g., to help elucidate mechanism of action or contribute to a weight-of-evidence approach) or for populating relevant comparative databases by encouraging parallel submissions of genomics data and traditional toxicologic test results.".
- Toxicogenomics wikiPageExternalLink cebs.niehs.nih.gov.
- Toxicogenomics wikiPageExternalLink ctdbase.org.
- Toxicogenomics wikiPageExternalLink toxcast.
- Toxicogenomics wikiPageExternalLink criticalpath.
- Toxicogenomics wikiPageExternalLink consortium.html.
- Toxicogenomics wikiPageExternalLink toxexpress-program.
- Toxicogenomics wikiPageExternalLink www.innomed-predtox.com.
- Toxicogenomics wikiPageExternalLink whatis.html.
- Toxicogenomics wikiPageExternalLink www.toxicogenomics.nl.
- Toxicogenomics wikiPageID "1677333".
- Toxicogenomics wikiPageRevisionID "593207581".
- Toxicogenomics hasPhotoCollection Toxicogenomics.
- Toxicogenomics subject Category:Genomics.
- Toxicogenomics subject Category:Toxicology.
- Toxicogenomics comment "Toxicogenomics is a field of science that deals with the collection, interpretation, and storage of information about gene and protein activity within particular cell or tissue of an organism in response to toxic substances. Toxicogenomics combines toxicology with genomics or other high throughput molecular profiling technologies such as transcriptomics, proteomics and metabolomics.".
- Toxicogenomics label "Toxicogenomica".
- Toxicogenomics label "Toxicogenomics".
- Toxicogenomics label "علم وراثة سمي".
- Toxicogenomics sameAs 독성유전체학.
- Toxicogenomics sameAs Toxicogenomica.
- Toxicogenomics sameAs m.05mnkt.
- Toxicogenomics sameAs Q841450.
- Toxicogenomics sameAs Q841450.
- Toxicogenomics wasDerivedFrom Toxicogenomics?oldid=593207581.
- Toxicogenomics homepage www.innomed-predtox.com.
- Toxicogenomics isPrimaryTopicOf Toxicogenomics.