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- Trilostane abstract "Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.It was withdrawn from human use in the United States market in April 1994. The drug is available in the United Kingdom for use in humans under the brand name Modrenal and is used for treatment of Cushing's disease and for breast cancer treatment. It was approved in the United States in 2008 for the treatment of Cushing's disease (hyperadrenocorticism) in dogs under the brand name Vetoryl. It was available by prescription in the UK under the Vetoryl brand name for some time before it was approved in the US. The drug is also used to treat the skin disorder Alopecia X in dogs.It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs. This prescription drug works by stopping the production of cortisol in the adrenal glands. In studies of the drug, the most common side effects were vomiting, lack of energy, diarrhea, and weight loss. Trilostane should not be given to a dog that:has kidney or liver disease;takes certain medications used to treat heart disease;[citation needed]is pregnant, nursing or intended for breeding The safety and effectiveness of trilostane were shown in several studies. Success was measured by improvements in both blood test results and physical symptoms (increased appetite and activity level, and decreased panting, thirst and urination).Only one other drug, Anipryl (veterinary brand name) selegiline, is FDA-approved to treat Cushing's disease in dogs, but only to treat uncomplicated, pituitary-dependent Cushing's. The only previous treatment for the disease was the use of Mitotane (brand name Lysodren) off-label.It has been used as a progesterone inhibitor.A number of compounding pharmacies in the US sell the product. Since the US approval of Vetoryl in December 2008, compounding pharmacies are no longer able to use a bulk drug product for compounding purposes, but must prepare the compounded drug from Vetoryl.It is a 3β-hydroxysteroid dehydrogenase inhibitor.".
- Trilostane atcPrefix "H02".
- Trilostane atcSuffix "CA01".
- Trilostane casNumber "13647-35-3".
- Trilostane chEBI "32260".
- Trilostane drugbank "DB01108".
- Trilostane fdaUniiCode "L0FPV48Q5R".
- Trilostane iupacName "(4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile".
- Trilostane pubchem "656583".
- Trilostane thumbnail Trilostane.svg?width=300.
- Trilostane wikiPageExternalLink SPC_183023.pdf.
- Trilostane wikiPageID "6495182".
- Trilostane wikiPageRevisionID "593216419".
- Trilostane atcPrefix "H02".
- Trilostane atcSuffix "CA01".
- Trilostane c "20".
- Trilostane casNumber "13647".
- Trilostane chebi "32260".
- Trilostane chembl "1200907".
- Trilostane chemspiderid "570949".
- Trilostane drugbank "DB01108".
- Trilostane eliminationHalfLife "28800.0".
- Trilostane h "27".
- Trilostane hasPhotoCollection Trilostane.
- Trilostane inchi "1".
- Trilostane inchikey "KVJXBPDAXMEYOA-CXANFOAXBX".
- Trilostane iupacName "-317".
- Trilostane kegg "D01180".
- Trilostane legalStatus "Veterinary use( )".
- Trilostane legalUk "POM".
- Trilostane metabolism "Hepatic".
- Trilostane molecularWeight "329.433".
- Trilostane n "1".
- Trilostane o "3".
- Trilostane pubchem "656583".
- Trilostane routesOfAdministration "oral".
- Trilostane smiles "N#C\C4=C[C@H]5O[C@]35[C@]C4".
- Trilostane stdinchi "1".
- Trilostane stdinchikey "KVJXBPDAXMEYOA-CXANFOAXSA-N".
- Trilostane unii "L0FPV48Q5R".
- Trilostane verifiedfields "changed".
- Trilostane verifiedrevid "470614898".
- Trilostane subject Category:Hormonal_agents.
- Trilostane subject Category:Nitriles.
- Trilostane subject Category:Oxidoreductase_inhibitors.
- Trilostane subject Category:Steroids.
- Trilostane subject Category:Withdrawn_drugs.
- Trilostane type Agent109190918.
- Trilostane type Agent114778436.
- Trilostane type CausalAgent100007347.
- Trilostane type Drug103247620.
- Trilostane type HormonalAgents.
- Trilostane type Inhibitor114724436.
- Trilostane type Matter100020827.
- Trilostane type OxidoreductaseInhibitors.
- Trilostane type PhysicalEntity100001930.
- Trilostane type Substance100020090.
- Trilostane type WithdrawnDrugs.
- Trilostane type Drug.
- Trilostane type DrugProduct.
- Trilostane type FunctionalSubstance.
- Trilostane comment "Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.It was withdrawn from human use in the United States market in April 1994. The drug is available in the United Kingdom for use in humans under the brand name Modrenal and is used for treatment of Cushing's disease and for breast cancer treatment. It was approved in the United States in 2008 for the treatment of Cushing's disease (hyperadrenocorticism) in dogs under the brand name Vetoryl.".
- Trilostane label "Trilostan".
- Trilostane label "Trilostane".
- Trilostane label "Trilostano".
- Trilostane sameAs Trilostan.
- Trilostane sameAs Trilostano.
- Trilostane sameAs m.0g7lbt.
- Trilostane sameAs Q907313.
- Trilostane sameAs Q907313.
- Trilostane sameAs DB01108.
- Trilostane sameAs Trilostane.
- Trilostane wasDerivedFrom Trilostane?oldid=593216419.
- Trilostane depiction Trilostane.svg.
- Trilostane isPrimaryTopicOf Trilostane.
