Matches in DBpedia 2014 for { <http://dbpedia.org/resource/UPF3A> ?p ?o. }
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- UPF3A abstract "Regulator of nonsense transcripts 3A is a protein that in humans is encoded by the UPF3A gene.This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene.".
- UPF3A entrezgene "65110".
- UPF3A wikiPageID "14875717".
- UPF3A wikiPageRevisionID "593239663".
- UPF3A hasPhotoCollection UPF3A.
- UPF3A requireManualInspection "no".
- UPF3A summaryText "This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene.".
- UPF3A updateCitations "yes".
- UPF3A updatePage "yes".
- UPF3A updateProteinBox "yes".
- UPF3A updateSummary "yes".
- UPF3A type Biomolecule.
- UPF3A type Protein.
- UPF3A type BiologicalObject.
- UPF3A comment "Regulator of nonsense transcripts 3A is a protein that in humans is encoded by the UPF3A gene.This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).".
- UPF3A label "UPF3A".
- UPF3A sameAs m.03g_wbj.
- UPF3A sameAs Q7865488.
- UPF3A sameAs Q7865488.
- UPF3A wasDerivedFrom UPF3A?oldid=593239663.
- UPF3A isPrimaryTopicOf UPF3A.