Matches in DBpedia 2014 for { <http://dbpedia.org/resource/UPF3B> ?p ?o. }
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- UPF3B abstract "Regulator of nonsense transcripts 3B is a protein that in humans is encoded by the UPF3B gene.This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.".
- UPF3B entrezgene "65109".
- UPF3B wikiPageID "14777979".
- UPF3B wikiPageRevisionID "593239670".
- UPF3B hasPhotoCollection UPF3B.
- UPF3B requireManualInspection "no".
- UPF3B summaryText "This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.".
- UPF3B updateCitations "yes".
- UPF3B updatePage "yes".
- UPF3B updateProteinBox "yes".
- UPF3B updateSummary "yes".
- UPF3B type Biomolecule.
- UPF3B type Protein.
- UPF3B type BiologicalObject.
- UPF3B comment "Regulator of nonsense transcripts 3B is a protein that in humans is encoded by the UPF3B gene.This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).".
- UPF3B label "UPF3B".
- UPF3B sameAs m.03gxqbx.
- UPF3B sameAs Q7865490.
- UPF3B sameAs Q7865490.
- UPF3B wasDerivedFrom UPF3B?oldid=593239670.
- UPF3B isPrimaryTopicOf UPF3B.