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- Ubiquitin_ligase abstract "A ubiquitin ligase (also called an E3 ubiquitin ligase) is a ligase enzyme that combines with a ubiquitin-containing E2 ubiquitin-conjugating enzyme, recognizes the target protein that is to be ubiquinated, and causes the attachment of ubiquitin to a lysine on the target protein via an isopeptide bond. An E3 ubiquitin ligase targets specific protein substrates for degradation by the proteasome. In general, the ubiquitin ligase is involved in poly-ubiquitination: a second ubiquitin is attached to the first, a third is attached to the second, and so forth. Poly-ubiquitination marks proteins for degradation by the proteasome.However, there are some ubiquitination events that are limited to mono-ubiquitination, in which only a single ubiquitin is added by the ubiquitin ligase to a substrate molecule. Mono-ubiquitinated proteins are not targeted to the proteasome for degradation, but may instead be altered in their cellular location or function, for example, via binding other proteins that have domains capable of binding ubiquitin.[citation needed]Further complicating matters, different lysines on ubiquitin can be targeted by an E3 to make chains. The most common lysine is Lys48 on the ubiquitin chain. This is the lysine used to make polyubiquitin, which is recognized by the proteasome. However, Lys63 can also be used, and chains using this lysine are important for DNA repair, among other functions.".
- Ubiquitin_ligase ecNumber "6.3.2.19".
- Ubiquitin_ligase thumbnail 4a4c.png?width=300.
- Ubiquitin_ligase wikiPageExternalLink quips?story=LordCBL.
- Ubiquitin_ligase wikiPageExternalLink www.pdbe.org.
- Ubiquitin_ligase wikiPageID "622571".
- Ubiquitin_ligase wikiPageRevisionID "603787930".
- Ubiquitin_ligase caption "E3 ubiquitin ligase Cbl in complex with E2 and substrate peptide . PDB entry".
- Ubiquitin_ligase casNumber "74812".
- Ubiquitin_ligase ecNumber "6.3".
- Ubiquitin_ligase goCode "51444".
- Ubiquitin_ligase hasPhotoCollection Ubiquitin_ligase.
- Ubiquitin_ligase iubmbEcNumber "6".
- Ubiquitin_ligase name "Ubiquitin—protein ligase".
- Ubiquitin_ligase subject Category:EC_6.3.
- Ubiquitin_ligase subject Category:Posttranslational_modification.
- Ubiquitin_ligase type Biomolecule.
- Ubiquitin_ligase type Enzyme.
- Ubiquitin_ligase type BiologicalObject.
- Ubiquitin_ligase comment "A ubiquitin ligase (also called an E3 ubiquitin ligase) is a ligase enzyme that combines with a ubiquitin-containing E2 ubiquitin-conjugating enzyme, recognizes the target protein that is to be ubiquinated, and causes the attachment of ubiquitin to a lysine on the target protein via an isopeptide bond. An E3 ubiquitin ligase targets specific protein substrates for degradation by the proteasome.".
- Ubiquitin_ligase label "Ubiquitin ligase".
- Ubiquitin_ligase label "Ubiquitine ligase".
- Ubiquitin_ligase label "Убиквитинлигаза".
- Ubiquitin_ligase label "泛素连接酶".
- Ubiquitin_ligase sameAs Ubiquitine_ligase.
- Ubiquitin_ligase sameAs m.02xnyy.
- Ubiquitin_ligase sameAs Q4274835.
- Ubiquitin_ligase sameAs Q4274835.
- Ubiquitin_ligase wasDerivedFrom Ubiquitin_ligase?oldid=603787930.
- Ubiquitin_ligase depiction 4a4c.png.
- Ubiquitin_ligase isPrimaryTopicOf Ubiquitin_ligase.
- Ubiquitin_ligase name "Ubiquitin—protein ligase".
