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- WAY-181,187 abstract "WAY-181,187 is a high affinity and selective 5-HT6 receptor full agonist. It induces robust increases in extracellular GABA levels in the frontal cortex, hippocampus, striatum, and amygdala of rats without affecting concentrations in the nucleus accumbens or thalamus, and has modest to no effects on norepinephrine, serotonin, dopamine, or glutamate levels in these areas. WAY-181,187 has demonstrated preclinical efficacy in rodent models of depression, anxiety, and notably obsessive-compulsive disorder, though it has also been shown to impair cognition and memory.".
- WAY-181,187 atcPrefix "none".
- WAY-181,187 casNumber "?".
- WAY-181,187 iupacName "2-(1-{6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl}-1H-indol-3-yl)ethan-1-amine".
- WAY-181,187 pubchem "10150497".
- WAY-181,187 thumbnail WAY-181,187.svg?width=300.
- WAY-181,187 wikiPageID "26753686".
- WAY-181,187 wikiPageRevisionID "593301371".
- WAY-181,187 atcPrefix "none".
- WAY-181,187 c "15".
- WAY-181,187 casNumber "?".
- WAY-181,187 chembl "392760".
- WAY-181,187 cl "1".
- WAY-181,187 h "13".
- WAY-181,187 hasPhotoCollection WAY-181,187.
- WAY-181,187 iupacName "2".
- WAY-181,187 molecularWeight "380.872".
- WAY-181,187 n "4".
- WAY-181,187 o "2".
- WAY-181,187 pubchem "10150497".
- WAY-181,187 s "2".
- WAY-181,187 smiles "NCCc1cnSc1cnc2sccn12".
- WAY-181,187 width "200".
- WAY-181,187 subject Category:Serotonin_receptor_agonists.
- WAY-181,187 type Drug.
- WAY-181,187 type FunctionalSubstance.
- WAY-181,187 comment "WAY-181,187 is a high affinity and selective 5-HT6 receptor full agonist. It induces robust increases in extracellular GABA levels in the frontal cortex, hippocampus, striatum, and amygdala of rats without affecting concentrations in the nucleus accumbens or thalamus, and has modest to no effects on norepinephrine, serotonin, dopamine, or glutamate levels in these areas.".
- WAY-181,187 label "WAY-181,187".
- WAY-181,187 sameAs m.0bmk0s8.
- WAY-181,187 sameAs Q487463.
- WAY-181,187 sameAs Q487463.
- WAY-181,187 wasDerivedFrom WAY-181,187?oldid=593301371.
- WAY-181,187 depiction WAY-181,187.svg.
- WAY-181,187 isPrimaryTopicOf WAY-181,187.
