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- WHSC2 abstract "Negative elongation factor A is a protein that in humans is encoded by the WHSC2 gene.This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. WHSC2 encodes the NELF-A subunit of the NELF complex.".
- WHSC2 entrezgene "7469".
- WHSC2 wikiPageID "14778056".
- WHSC2 wikiPageRevisionID "593313063".
- WHSC2 hasPhotoCollection WHSC2.
- WHSC2 requireManualInspection "no".
- WHSC2 summaryText "This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. WHSC2 encodes the NELF-A subunit of the NELF complex.".
- WHSC2 updateCitations "yes".
- WHSC2 updatePage "yes".
- WHSC2 updateProteinBox "yes".
- WHSC2 updateSummary "no".
- WHSC2 type Biomolecule.
- WHSC2 type Protein.
- WHSC2 type BiologicalObject.
- WHSC2 comment "Negative elongation factor A is a protein that in humans is encoded by the WHSC2 gene.This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4.".
- WHSC2 label "WHSC2".
- WHSC2 sameAs m.03gxqdz.
- WHSC2 sameAs Q7950420.
- WHSC2 sameAs Q7950420.
- WHSC2 wasDerivedFrom WHSC2?oldid=593313063.
- WHSC2 isPrimaryTopicOf WHSC2.