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- Wortmannin abstract "Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces (Penicillium) wortmannii,is a specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. It displays a similar potency in vitro for the class I, II, and III PI3K members although it can also inhibit other PI3K-related enzymes such as mTOR, DNA-PK, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high concentrations , Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K. The half-life of wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI3K. Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation[citation needed].".
- Wortmannin thumbnail Wortmannin_chemical_structure.png?width=300.
- Wortmannin wikiPageExternalLink ?ligand=KWT.
- Wortmannin wikiPageExternalLink wortmannin.htm.
- Wortmannin wikiPageExternalLink overview.html.
- Wortmannin wikiPageID "1607079".
- Wortmannin wikiPageRevisionID "575380476".
- Wortmannin hasPhotoCollection Wortmannin.
- Wortmannin imagefile "Wortmannin chemical structure.png".
- Wortmannin verifiedfields "changed".
- Wortmannin verifiedrevid "393946468".
- Wortmannin watchedfields "changed".
- Wortmannin subject Category:Acetate_esters.
- Wortmannin subject Category:Furans.
- Wortmannin subject Category:Lactones.
- Wortmannin subject Category:Phosphoinositide_3-kinase_inhibitors.
- Wortmannin type Abstraction100002137.
- Wortmannin type AcetateEsters.
- Wortmannin type Chemical114806838.
- Wortmannin type Compound114818238.
- Wortmannin type Ester114850483.
- Wortmannin type Furan114876318.
- Wortmannin type Furans.
- Wortmannin type Material114580897.
- Wortmannin type Matter100020827.
- Wortmannin type OrganicCompound114727670.
- Wortmannin type Part113809207.
- Wortmannin type PhysicalEntity100001930.
- Wortmannin type Relation100031921.
- Wortmannin type Substance100019613.
- Wortmannin type ChemicalCompound.
- Wortmannin type ChemicalSubstance.
- Wortmannin type ChemicalSubstanceType.
- Wortmannin type ChemicalObject.
- Wortmannin type Thing.
- Wortmannin comment "Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces (Penicillium) wortmannii,is a specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor.".
- Wortmannin label "Wortmannin".
- Wortmannin label "Wortmannin".
- Wortmannin label "Вортманнин".
- Wortmannin sameAs Wortmannin.
- Wortmannin sameAs m.05g6p6.
- Wortmannin sameAs Q423565.
- Wortmannin sameAs Q423565.
- Wortmannin sameAs Wortmannin.
- Wortmannin wasDerivedFrom Wortmannin?oldid=575380476.
- Wortmannin depiction Wortmannin_chemical_structure.png.
- Wortmannin isPrimaryTopicOf Wortmannin.