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- XAF1 abstract "XIAP-associated factor 1 is a protein that in humans is encoded by the XAF1 gene.X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001).[supplied by OMIM]".
- XAF1 entrezgene "54739".
- XAF1 wikiPageID "14799513".
- XAF1 wikiPageRevisionID "593335142".
- XAF1 hasPhotoCollection XAF1.
- XAF1 requireManualInspection "no".
- XAF1 summaryText "X-linked inhibitor of apoptosis is a potent member of the IAP family. All members of this family possess baculoviral IAP repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases . XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells .[supplied by OMIM]".
- XAF1 updateCitations "yes".
- XAF1 updatePage "yes".
- XAF1 updateProteinBox "yes".
- XAF1 updateSummary "yes".
- XAF1 type Biomolecule.
- XAF1 type Protein.
- XAF1 type BiologicalObject.
- XAF1 comment "XIAP-associated factor 1 is a protein that in humans is encoded by the XAF1 gene.X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity.".
- XAF1 label "XAF1".
- XAF1 sameAs m.03gydbb.
- XAF1 sameAs Q8041675.
- XAF1 sameAs Q8041675.
- XAF1 wasDerivedFrom XAF1?oldid=593335142.
- XAF1 isPrimaryTopicOf XAF1.