Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Xbra> ?p ?o. }
Showing items 1 to 12 of
12
with 100 items per page.
- Xbra abstract "Xbra is a homologue of Brachyury (T) gene for Xenopus. It is a transcription activator involved in vertebrate gastrulation which controls posterior mesoderm patterning and notochord differentiation by activating transcription of genes expressed throughout mesoderm. The effects of Xbra is concentration dependent where concentration gradient controls the development of specific types of mesoderm in Xenopus. Low concentrations of Xbra induce ventral mesoderm while high concentration stimulates the formation of muscle.Posterior mesoderm development presents two types of cell behaviors, cell migration and convergent extension, in prechordal mesoderm and chordamesoderm cells, respectively. Cell migration is exhibited by the prechordal mesoderm cells, resulting in the formation of the future anterior end. Xbra induces convergent extension which inhibits cell migration and rearranges the chordamesoderm cells into a structure that will later differentiate into notochord. As a result, Xbra acts as a switch to convert between these two behaviors.Xbra is able to activate itself indirectly, specifically for dorsal mesoderm, through FGF signaling while eFGF maintains Xbra expression, creating an autoregulatory loop.Inhibition of Xbra leads to abnormal patterning of mesoderm, such as shortened trunk. In a previous study, the activation domain of Xbra was replaced by repressor domain of Drosophila engrailed protein in order to form a dominant-interfering Xbra construct that would help to study the function and regulation of Xbra. The injection of RNA encoding this construct has led to various birth defects such as defective blastopore closure and abnormal notochord differentiation in the developing embryo. ".
- Xbra wikiPageID "42497844".
- Xbra wikiPageRevisionID "605417828".
- Xbra subject Category:Transcription_factors.
- Xbra subject Category:Xenopus.
- Xbra comment "Xbra is a homologue of Brachyury (T) gene for Xenopus. It is a transcription activator involved in vertebrate gastrulation which controls posterior mesoderm patterning and notochord differentiation by activating transcription of genes expressed throughout mesoderm. The effects of Xbra is concentration dependent where concentration gradient controls the development of specific types of mesoderm in Xenopus.".
- Xbra label "Xbra".
- Xbra sameAs m.010f4qkq.
- Xbra sameAs Q17143298.
- Xbra sameAs Q17143298.
- Xbra wasDerivedFrom Xbra?oldid=605417828.
- Xbra isPrimaryTopicOf Xbra.