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- YkoK_leader abstract "The Ykok leader or M-box is a Mg2+-sensing RNA structure that controls the expression of Magnesium ion transport proteins in bacteria. It is a distinct structure to the Magnesium responsive RNA element.The Ykok leader was originally described as a conserved sequence with potential riboswitch function found upstream of the B. subtilis ykoK gene and genes with related functions in other bacteria. Examples of the conserved M-box RNA structure occur upstream of each of the three major families of Mg2+ transporters (CorA, MgtE and MgtA/MgtB) in various bacterial species.The molecular structure of the M-box example upstream of the B. subtilis ykoK gene includes six bound Mg2+ ions. Biochemical studies indicate that this M-Box RNA compacts in the presence of Mg2+ and other divalent ions. This folding process appears to disrupt an antiterminator structure, and thereby allow a transcription terminator structure to form. As expected from this model, B. subtilis cells repress expression of a downstream reporter gene when grown in the presence of Mg2+. Therefore, the M-box appears to function as a genetic "off" switch that is important for maintaining Mg2+ homeostasis in bacteria.".
- YkoK_leader thumbnail RF00380.jpg?width=300.
- YkoK_leader wikiPageExternalLink explore.do?structureId=2QBZ.
- YkoK_leader wikiPageID "11485448".
- YkoK_leader wikiPageRevisionID "490309368".
- YkoK_leader caption "Predicted secondary structure and sequence conservation of ykoK".
- YkoK_leader hasPhotoCollection YkoK_leader.
- YkoK_leader id "RF00380".
- YkoK_leader name "ykoK leader".
- YkoK_leader rfam "RF00380".
- YkoK_leader rnaType Cis-regulatory_element.
- YkoK_leader symbol "ykoK".
- YkoK_leader taxDomain Bacteria.
- YkoK_leader subject Category:Cis-regulatory_RNA_elements.
- YkoK_leader subject Category:Riboswitch.
- YkoK_leader type Abstraction100002137.
- YkoK_leader type Cis-regulatoryRNAElements.
- YkoK_leader type Cognition100023271.
- YkoK_leader type Component105868954.
- YkoK_leader type Concept105835747.
- YkoK_leader type Content105809192.
- YkoK_leader type Idea105833840.
- YkoK_leader type Part105867413.
- YkoK_leader type PsychologicalFeature100023100.
- YkoK_leader comment "The Ykok leader or M-box is a Mg2+-sensing RNA structure that controls the expression of Magnesium ion transport proteins in bacteria. It is a distinct structure to the Magnesium responsive RNA element.The Ykok leader was originally described as a conserved sequence with potential riboswitch function found upstream of the B. subtilis ykoK gene and genes with related functions in other bacteria.".
- YkoK_leader label "YkoK leader".
- YkoK_leader sameAs m.02rfghj.
- YkoK_leader sameAs Q8053984.
- YkoK_leader sameAs Q8053984.
- YkoK_leader sameAs YkoK_leader.
- YkoK_leader wasDerivedFrom YkoK_leader?oldid=490309368.
- YkoK_leader depiction RF00380.jpg.
- YkoK_leader isPrimaryTopicOf YkoK_leader.
