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- ZIC2 abstract "ZIC2 is a member of the Zinc finger of the cerebellum (ZIC) protein family.ZIC2 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. Correct function of these proteins in critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, mutation of ZIC2 is known to result in holoprosencephaly due to defect in the function of the organizer region (node), which leads to a defective anterior notochord (ANC). The ANC provides a maintenance signal to the Prechordal plate (PCP), thus a defective ANC results in degradation of the PCP, which is normally responsible for sending a shh signal to the developing forebrain resulting in the formation of the two hemispheres. Holoprosencephaly is the most common structural anomaly of the human forebrain.A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects (spina bifida). This gene is closely linked to a gene encoding ZIC5, a related family member on chromosome 13.".
- ZIC2 entrezgene "7546".
- ZIC2 wikiPageID "14878655".
- ZIC2 wikiPageRevisionID "593553625".
- ZIC2 hasPhotoCollection ZIC2.
- ZIC2 requireManualInspection "no".
- ZIC2 summaryText "ZIC2 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. Correct function of these proteins in critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, mutation of ZIC2 is known to result in holoprosencephaly due to defect in the function of the organizer region , which leads to a defective anterior notochord . The ANC provides a maintenance signal to the Prechordal plate , thus a defective ANC results in degradation of the PCP, which is normally responsible for sending a shh signal to the developing forebrain resulting in the formation of the two hemispheres. Holoprosencephaly is the most common structural anomaly of the human forebrain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects . This gene is closely linked to a gene encoding ZIC5, a related family member on chromosome 13.".
- ZIC2 updateCitations "yes".
- ZIC2 updatePage "yes".
- ZIC2 updateProteinBox "yes".
- ZIC2 updateSummary "yes".
- ZIC2 type Biomolecule.
- ZIC2 type Protein.
- ZIC2 type BiologicalObject.
- ZIC2 comment "ZIC2 is a member of the Zinc finger of the cerebellum (ZIC) protein family.ZIC2 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. Correct function of these proteins in critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects.".
- ZIC2 label "ZIC2".
- ZIC2 sameAs m.03h014x.
- ZIC2 sameAs Q8063102.
- ZIC2 sameAs Q8063102.
- ZIC2 sameAs ZIC2.
- ZIC2 wasDerivedFrom ZIC2?oldid=593553625.
- ZIC2 isPrimaryTopicOf ZIC2.