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- catalog abstract "Gout and uric acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of uric acid excretion, although still posing difficult problems, appears to approach clarification. In view of the intensive research on purine metabolism going on in various laboratories all over the world it was felt by several investigators in this field that the time was appropriate to convene a symposium dedicated to this subject. This book is the first of its kind, was therefore organized and held in Tel-Aviv, June 17 to 22, 1973. The meeting dealt with the various aspects of purine metabolism and its disorders - biochemistry, enzyme mutations, genetics, methodology, clinical aspects and treatment. This volume contains the full reports of all communications made at the symposium.".
- catalog contributor b3635730.
- catalog contributor b3635731.
- catalog contributor b3635732.
- catalog contributor b3635733.
- catalog contributor b3635734.
- catalog contributor b3635735.
- catalog contributor b3635736.
- catalog created "[1974]".
- catalog date "1974".
- catalog date "[1974]".
- catalog dateCopyrighted "[1974]".
- catalog description "Contents. - v. 1. Enzymes and metabolic pathways. - v. 2. Biochemistry and pharmacology of uric acid metabolism.".
- catalog description "Gout and uric acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of uric acid excretion, although still posing difficult problems, appears to approach clarification. In view of the intensive research on purine metabolism going on in various laboratories all over the world it was felt by several investigators in this field that the time was appropriate to convene a symposium dedicated to this subject. This book is the first of its kind, was therefore organized and held in Tel-Aviv, June 17 to 22, 1973. The meeting dealt with the various aspects of purine metabolism and its disorders - biochemistry, enzyme mutations, genetics, methodology, clinical aspects and treatment. This volume contains the full reports of all communications made at the symposium.".
- catalog description "Includes bibliographical references.".
- catalog extent "2 v.".
- catalog hasFormat "Purine metabolism in man: enzymes and metabolic pathways.".
- catalog identifier "0306390957 (v. 1)".
- catalog isFormatOf "Purine metabolism in man: enzymes and metabolic pathways.".
- catalog isPartOf "Advances in experimental medicine and biology, v. 41".
- catalog issued "1974".
- catalog issued "[1974]".
- catalog language "eng".
- catalog publisher "New York, Plenum Press".
- catalog relation "Purine metabolism in man: enzymes and metabolic pathways.".
- catalog subject "612/.39".
- catalog subject "Purine-Pyrimidine Metabolism, Inborn Errors congresses.".
- catalog subject "Purines Metabolism Congresses.".
- catalog subject "Purines metabolism congresses.".
- catalog subject "QP801.P8 I56 1973".
- catalog subject "Uric acid Metabolism Congresses.".
- catalog subject "W1 AD559 v. 41 QU58 I635p 1973".
- catalog tableOfContents "Contents. - v. 1. Enzymes and metabolic pathways. - v. 2. Biochemistry and pharmacology of uric acid metabolism.".
- catalog title "Purine metabolism in man: enzymes and metabolic pathways; [proceedings] Edited by Oded Sperling and Andre De Vries and James B. Wyngaarden.".
- catalog type "Conference proceedings. fast".
- catalog type "text".