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• catalog abstract "This is the first comprehensive review of the neutralization of animal viruses for several decades, intended to provide a clear exposition of current knowledge and to outline avenues for future research. The approach is mechanistic; the aim is to understand the process of neutralization and, ultimately, to determine how neutralizing and/or protective antibody can be stimulated in vivo. Chapters discuss the ways in which neutralizing IgG, A and M affect the interactions of virus with its host cell, quantitative aspects of neutralization, neutralization by fragments of antibody, neutralization in vivo, and the evolutionary significance of the possession of neutralization sites. In addition, individual chapters are devoted to the neutralization of poliovirus, influenza virus and HIV.".
• catalog contributor b6972686.
• catalog created "1993.".
• catalog date "1993".
• catalog date "1993.".
• catalog dateCopyrighted "1993.".
• catalog description "(cont) IgM neutralization -- IgA neutralization -- IgG neutralization -- Neutralization of HIV-1: a summary.".
• catalog description "(cont) Properties of protein and peptide antigens which elicit neutralizing antibody -- Neutralization in vivo -- Complement and neutralization -- Neutralization by inhibition of release of progeny virus from the infected cell -- Changes in virus proteins and virion structure on binding antibody, including synergistic neutralization -- Reversibility of neutralization -- Neutralization by fragments of antibody -- Quantitative aspects of neutralization -- Unconventional neutralization -- Genetic engineering of antibodies and viruses -- Anti-idiotype antibodies and neutralization -- Evolutionary significance of neutralization sites -- Why do viruses have neutralization sites? -- Strategies which avoid or minimize expression of, or response, to neutralization sites -- Relating to the virus particle -- Relating to the immune system -- Neutralization of poliovirus and rhinovirus: a summary -- Attachment -- Internalization -- Post-internalization -- Aggregation -- Conformational changes on binding antibody -- Neutralization of type A influenza virus by immunoglobulins M, A and G: a summary.".
• catalog description "Immunoglobulin G neutralization by inhibition of attachment of virus to the cell -- Immunoglobulin G neutralization which does not inhibit attachment of virus to the cell -- Immunoglobulin G neutralization by aggregation of virions -- Immunoglobulin G neutralization mechanisms which operate after attachment of the virus: antibody complex to a cell receptor unit -- Inhibition of fusion at the plasma membrane -- Inhibition of endocytosis -- Inhibition of fusion of viral and cellular membranes -- Inhibition of non-fusion uncoating -- Inhibition of events which occur after primary uncoating -- Neutralization which occurs by virus binding antibody after it has attached to a cell -- Role of the cell in neutralization -- Antibody-dependent enhancement of infectivity by neutralizing antibody: Fc and complement receptors -- Neutralization by polymeric immunoglobulin A -- Neutralization by immunoglobulin M -- Relevance of immunoglobulin isotype to neutralization -- Viral carbohydrates, proteins and neutralization -- Carbohydrates and neutralization -- Proteins and neutralization.".
• catalog description "Includes bibliographical references (p. [112]-146) and index.".
• catalog description "This is the first comprehensive review of the neutralization of animal viruses for several decades, intended to provide a clear exposition of current knowledge and to outline avenues for future research. The approach is mechanistic; the aim is to understand the process of neutralization and, ultimately, to determine how neutralizing and/or protective antibody can be stimulated in vivo. Chapters discuss the ways in which neutralizing IgG, A and M affect the interactions of virus with its host cell, quantitative aspects of neutralization, neutralization by fragments of antibody, neutralization in vivo, and the evolutionary significance of the possession of neutralization sites. In addition, individual chapters are devoted to the neutralization of poliovirus, influenza virus and HIV.".
• catalog extent "vi, 149 p. :".
• catalog identifier "0387560300 (alk. paper)".
• catalog identifier "3540560300 (alk. paper)".
• catalog isPartOf "Current topics in microbiology and immunology, 0070-217X ; 183".
• catalog issued "1993".
• catalog issued "1993.".
• catalog language "eng".
• catalog publisher "Berlin ; New York : Springer-Verlag,".
• catalog subject "Antibodies, Viral immunology.".
• catalog subject "Antiviral Agents immunology.".
• catalog subject "Attachment mechanisms (Biology)".
• catalog subject "Immunoglobulin G Immunology.".
• catalog subject "Immunoglobulins immunology.".
• catalog subject "QR180 .C87 v.183".
• catalog subject "QW 160 D582n 1993".
• catalog subject "Viral antibodies Immunological aspects.".
• catalog subject "Viruses immunology.".
• catalog subject "W1 CU82K v.183 1993".
• catalog tableOfContents "(cont) IgM neutralization -- IgA neutralization -- IgG neutralization -- Neutralization of HIV-1: a summary.".
• catalog tableOfContents "(cont) Properties of protein and peptide antigens which elicit neutralizing antibody -- Neutralization in vivo -- Complement and neutralization -- Neutralization by inhibition of release of progeny virus from the infected cell -- Changes in virus proteins and virion structure on binding antibody, including synergistic neutralization -- Reversibility of neutralization -- Neutralization by fragments of antibody -- Quantitative aspects of neutralization -- Unconventional neutralization -- Genetic engineering of antibodies and viruses -- Anti-idiotype antibodies and neutralization -- Evolutionary significance of neutralization sites -- Why do viruses have neutralization sites? -- Strategies which avoid or minimize expression of, or response, to neutralization sites -- Relating to the virus particle -- Relating to the immune system -- Neutralization of poliovirus and rhinovirus: a summary -- Attachment -- Internalization -- Post-internalization -- Aggregation -- Conformational changes on binding antibody -- Neutralization of type A influenza virus by immunoglobulins M, A and G: a summary.".
• catalog tableOfContents "Immunoglobulin G neutralization by inhibition of attachment of virus to the cell -- Immunoglobulin G neutralization which does not inhibit attachment of virus to the cell -- Immunoglobulin G neutralization by aggregation of virions -- Immunoglobulin G neutralization mechanisms which operate after attachment of the virus: antibody complex to a cell receptor unit -- Inhibition of fusion at the plasma membrane -- Inhibition of endocytosis -- Inhibition of fusion of viral and cellular membranes -- Inhibition of non-fusion uncoating -- Inhibition of events which occur after primary uncoating -- Neutralization which occurs by virus binding antibody after it has attached to a cell -- Role of the cell in neutralization -- Antibody-dependent enhancement of infectivity by neutralizing antibody: Fc and complement receptors -- Neutralization by polymeric immunoglobulin A -- Neutralization by immunoglobulin M -- Relevance of immunoglobulin isotype to neutralization -- Viral carbohydrates, proteins and neutralization -- Carbohydrates and neutralization -- Proteins and neutralization.".
• catalog title "Neutralization of animal viruses / N.J. Dimmock.".
• catalog type "text".